Preparation method of p-hydroxybenzaldehyde

A technology of p-hydroxybenzaldehyde and hydroxymandelic acid, which is applied in the field of preparation of p-hydroxybenzaldehyde, can solve the problems of increasing production risk, increasing production cost, and high price, and achieves the enhancement of electron cloud density and reduction of by-products Effects that are easy to generate and manipulate

Active Publication Date: 2021-07-16
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is the use of p-cresol (relative to phenol), which is more expensive as a raw material; the use of expensive metal compound catalysts and supports, which need to be prepared and processed before use, which increases production costs; due to the use of methanol in the production process, methanol is produced here Explosive under certain conditions, increasing the risk of production

Method used

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  • Preparation method of p-hydroxybenzaldehyde
  • Preparation method of p-hydroxybenzaldehyde
  • Preparation method of p-hydroxybenzaldehyde

Examples

Experimental program
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Effect test

Embodiment 1

[0042] The iron nitrate was 40.2 g (0.10 mol) and copper nitrate was dissolved in 390.0 g of distilled water, and the solution pH was adjusted to 9 precipitation, filtered, and washed with 25% ammonia water. After drying 2-4 h at 120 ° C, calcined at 550 ° C for 2-4 h, and the finished product was projection A.

Embodiment 2

[0044] 48.4 g (0.20 mol) and copper nitrate were dissolved in 604.0 g of distilled water, and the pH of the solution was adjusted to 9 precipitation, filtered, and washed with 25% ammonia water. After drying 2-4 h at 120 ° C, calcined at 550 ° C for 2-4 h, and the finished product was projection B.

Embodiment 3

[0046] Nitrate 72.6 g (0.30 mol) and copper nitrate were dissolved in 822.0 g of distilled water, and the solution pH of the solution was adjusted to 9 precipitation, filtered, and washed with 25% ammonia water. After drying at 120 ° C, 2-4 h was calcined at 550 ° C, and the finished product was projected.

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Abstract

The invention relates to a preparation method of p-hydroxybenzaldehyde, which comprises the steps of (1) by taking aluminum salt and / or zinc salt as a catalyst, carrying out condensation reaction on phenol and glyoxylic acid under an alkaline condition to obtain 4-hydroxymandelic acid; and (2) oxidizing 4-hydroxymandelic acid serving as a raw material with copper ferrite serving as a catalyst to obtain p-hydroxybenzaldehyde. Compared with the prior art, the method has the advantages of easily available raw materials, mild reaction conditions, high yield and the like.

Description

Technical field [0001] The present invention relates to the field of organic synthesis, and more particularly to the preparation method of hydroxybenzal formaldehyde. Background technique [0002] In terms of fragrance, there are many precious spices that can be synthesized to hydroxybenzal kerofinder, with vanillin, foreign jasperdehyde, cloves, fennel brain, raspoids and other precious spices. In medicine, the hydroxybenzaldehyde is mainly used in synthesizing antibacterial synthetic methoxybenzylamine pyrimidine, hydroxybenamycin, hydroxybenzylcorin, trimethoxyladehyde, hydroxymethol glucose, hydroxybenzene glycid, disaster Mu Duu, artificial Tianma, Allow, etc., can also synthesize anti-high pressure, antihypertensive, cardiovascular disease, drugs for treating skin diseases and eye diseases, etc .; in agriculture, hydroxybenzaldehyde can synthesize enemy grass Nitrile and bromobinozoitrile; can also be used in synthetic food additives, new dyes, functional materials, chemica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/39C07C47/565C07C51/367C07C59/54B01J23/745
CPCC07C51/367C07C45/39B01J23/745C07C59/54C07C47/565
Inventor 章平毅毛海舫姚跃良刘吉波王朝阳王洪朝袁平徐露许芬焦炳熹
Owner SHANGHAI INST OF TECH
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