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Colloidal gold test paper for novel coronavirus as well as preparation method and application of colloidal gold test paper

A technology for detecting test strips and colloidal gold, which is applied in biological testing, measuring devices, immunoassays, etc., can solve the problems of low positive coincidence rate, achieve high positive coincidence rate, improve detection sensitivity, and protect protein activity.

Active Publication Date: 2021-07-09
SHANGHAI BIOGERM MEDICAL TECH CO LTD
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  • Abstract
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Problems solved by technology

[0003] The purpose of the present invention is to solve the existing novel coronavirus colloidal gold detection test paper and its preparation method and application, to solve the problem of low positive coincidence rate when the new coronavirus IgM and IgG antibody colloidal gold detection test paper detects

Method used

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  • Colloidal gold test paper for novel coronavirus as well as preparation method and application of colloidal gold test paper
  • Colloidal gold test paper for novel coronavirus as well as preparation method and application of colloidal gold test paper
  • Colloidal gold test paper for novel coronavirus as well as preparation method and application of colloidal gold test paper

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Embodiment Construction

[0038] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the accompanying drawings, in which several embodiments of the present invention are shown, however, the present invention can be realized in many different forms and is not limited herein The described embodiments are, on the contrary, provided so that the disclosure of the invention will be thorough.

[0039] A colloidal gold detection test paper for novel coronavirus provided by the present invention is combined below Figure 1 , Figure IIAs shown, a new coronavirus IgM and IgG antibody colloidal gold detection test paper of the present invention includes a CT box 13, a colloidal gold immunochromatography test strip 12 and a sample buffer, wherein the CT box 13 is a colloidal gold immunochromatography test paper The outer shell structure of the bar, the CT box 13 includes a sample injection hole 10 and an observation window 1...

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Abstract

The invention provides a colloidal gold test paper for novel coronavirus as well as a preparation method and application of the colloidal gold test paper. The kit provided by the invention is high in detection positive coincidence rate. A gold-labeled conjugate pad is respectively labeled by S protein and N protein of the novel coronavirus, an IgM antibody and an IgG antibody aiming at the S protein of the novel coronavirus and an IgM antibody and an IgG antibody aiming at the N protein of the novel coronavirus in a sample can be simultaneously identified; and meanwhile, the pH value of the S protein gold label is 7.5+ / -0.5, and the gold-labeled S protein is uniformly paved on the conjugate pad; the pH value of the N protein gold label is 9.5+ / -0.5, and the gold-labeled N protein is sprayed on the conjugate pad by adopting a gold spraying film scratching instrument; colloidal gold particles are fired by adopting a spherical bottle and a digital display jacket type magnetic stirrer in a differentiated gold labeling and treatment mode for the S protein and the N protein, and a surfactant lauryl polyoxyethylene ether sodium sulfate is added into a buffer solution 1 and a buffer solution 2, so that the detection sensitivity can be greatly improved, and the overall detection efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of novel coronavirus detection, and specifically relates to a novel coronavirus colloidal gold detection test paper and its preparation method and application. Background technique [0002] Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the group of coronaviruses and is the pathogen that causes the outbreak of coronavirus disease 2019. Coronaviruses are a type of zoonotic single-stranded RNA viruses that spread between animals and humans. Coronaviruses can infect mammals and birds, causing digestive tract diseases in cattle and pigs or upper respiratory tract diseases in chickens. Before the discovery of SARS-CoV-2, it was common in nature. There are six known coronaviruses that can infect humans, and four low-risk types, which mainly cause cold symptoms. They are human coronavirus 229E (HCoV-229E), Human coronavirus OC43 (HCoV-OC43), human coronavirus NL63 (HCoV-NL63), human corona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/569G01N33/558G01N33/58G01N33/532G01N33/531
CPCG01N33/6854G01N33/56983G01N33/558G01N33/587G01N33/532G01N33/531G01N2333/165G01N2469/20
Inventor 魏鹏海朱兆奎梁权赵百慧
Owner SHANGHAI BIOGERM MEDICAL TECH CO LTD
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