Small molecule peptides in hd therapeutic drugs and their application

A technology of small molecule polypeptides and therapeutic drugs, which is applied in the field of biomedicine to achieve highly specific effects

Active Publication Date: 2021-10-01
NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no effective treatment for the disease, and treatment options are limited to improving the symptoms of the disorder

Method used

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  • Small molecule peptides in hd therapeutic drugs and their application
  • Small molecule peptides in hd therapeutic drugs and their application
  • Small molecule peptides in hd therapeutic drugs and their application

Examples

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Embodiment Construction

[0022] The invention is further clarified in conjunction with the accompanying drawings and specific embodiments, and it is to be understood that these examples are intended to illustrate the invention only and are not intended to limit the scope of the invention, and those skilled in the < The modification of the equivalent form falls in the range as defined in the claims appended claims.

[0023] Design screening of small molecule polypeptides

[0024] like figure 1 As shown, DYNAMIN-RelatedProtein 1, mitochondrome dynamic associated protein 1) (HUMAN, NP_036192) and HSF1 (HUMAN, NP_005517) were determined using the L-Align sequence alignment software. Homologous domains, sequences and location figure 1 Down. The corresponding domain deletion truncation is constructed, and the mitochondrial transition of HSF1 is detected with DRP1. Immunoprecipitation verification interaction area, Western blot, protein blotting) results figure 1 The Chinese B shows the HR-A / B (HSF1 domain fix...

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Abstract

The present invention relates to a small molecule polypeptide in HD treatment medicine and application thereof, the amino acid sequence of the small molecule polypeptide is shown in SEQ ID No.1. The invention also provides the application of the small molecule polypeptide. The present invention designs a small molecule polypeptide DH1 through the research on the translocation mechanism and function of HSF1. The polypeptide inhibits the mitochondrial translocation of HSF1, weakens the fragmentation of mitochondria, increases the expression of mitochondrial DNA, and then achieves the purpose of protecting neurons and improving the disease process of HD, and provides a new target for HD treatment.

Description

Technical field [0001] The present invention relates to a small molecule polypeptide in an HD therapeutic drug and its applications thereof, belonging to the field of biomedical technology. Background technique [0002] Huntington's Disease (HD) is a commonly stained dominant genetic disease, which is caused by amplification of CAG repeating zone in Huntington protein gene exon 1. Although Huntington protein (HTT) is expressed in whole body, polyglutamine extension protein is particularly toxic in the intermediate multi-spinite and its cortex in the strain body. Patients suffer from emotional symptoms including depression and anxiety, as well as characteristic athletics and dance diseases. At present, there is no effective treatment in the disease, and the treatment selection is limited to improving the loss of loss. In IPSCs derived from HD transgenic mice, HD model Mouse Yac128, HD patients, Fibroblast, and HD patients, the heat shock transcription factor 1, is a significant mi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/47A61K38/17A61P25/14
CPCA61K38/00A61P25/14C07K14/4702
Inventor 郭兴付自醒刘纯月王晓嵩姜月晴
Owner NANJING MEDICAL UNIV
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