Parkinson disease evolution key module identification method based on miRNA sequencing data
A technology of sequencing data and key modules, applied in the field of biological information, can solve the problems of difficult to use heuristic algorithm and not very good effect.
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[0042] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, and the present invention includes but not limited to the following embodiments.
[0043] like figure 1 As shown, the present invention provides a method for identifying key modules of Parkinson's disease evolution based on miRNA sequencing data, and its specific implementation process is as follows:
[0044] 1. High-throughput sequencing data preprocessing
[0045] First, use fastp and fastxtoolkits software to perform quality control on high-throughput sequencing data (TCGA data), including removing N-base sequences, filtering sequences with low Q20 ratios, and performing length filtering. The data obtained after quality control is recorded as clean-data, and then in order to improve the next comparison task, deduplicate and count the repeated sequences in clean-data, and record the result as uniq-data. The data format of uniq-data is fasta, mainly com...
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