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Medicine for treating intractable epilepsy and preparation method thereof

A technology for refractory epilepsy and drugs, applied in the field of medicine, can solve problems such as affecting pharmacological effects, large differences in chemical structures, and increasing uncertainty in clinical safety, so as to improve pharmacological activity, repair nerves in the brain, enhance absorption effect

Inactive Publication Date: 2021-06-25
黑龙江汉普康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the application of cannabis active substances in the above-mentioned patents is the combined application of one or two monomeric compounds with certain pharmacological effects isolated and extracted from cannabis, or the active monomers have a clear Drugs with pharmacological therapeutic effects are used in combination, and the chemical structures of the active monomers used in combination are quite different, and they belong to different subtype structures in phytocannabinoids. For example, hypotetrahydrocannabinol belongs to the Δ9-THC structure , cannabidiol belongs to the cannabidiol type structure, so the existing active monomers in cannabis or the combined application of active monomers have obvious limitations, because their chemical structures belong to different cannabinoid structural subgroups When used in combination, it cannot exert pharmacological synergy, and there are certain differences in its pharmacokinetic behavior in the body after entering the human body, and it is impossible to complete the consistency of absorption and metabolism time, which affects its pharmacological effect to a certain extent. , also increased uncertainty in clinical safety

Method used

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  • Medicine for treating intractable epilepsy and preparation method thereof
  • Medicine for treating intractable epilepsy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A drug for the treatment of difficult epilepsy, including cannabis extract 10g, Tianma extract 2g and ice sheet 0.2g, manufactured by the following preparation method, including the following steps:

[0043] Step S1, prepare cannabis extract;

[0044] Step S2, prepare the generic extract;

[0045] Step S3, the obtained cannabis extract 10g, and the mephae extract 2G and 0.2 g of the ice sheet and the microcrystalline cellulose 12g are mixed;

[0046] Step S4, the mixed uniform material is employed by 80% ethanol for pharmaceutical granulation, over 20 mesh screen, and then drying at a temperature of 40 ° C;

[0047] Step S5, over 16 mesh sieves, mixed with a particle weight of 1%, and mix well, and the tablets are obtained.

[0048] Wherein, step S1 includes the following steps:

[0049] Step S11, place the dry process hemp in the oven for drying treatment, drying for 4 hours at 80 ° C temperature conditions, drying it after drying, pulverizing the medicinal material dry po...

Embodiment 2

[0062] A drug for treating refractory epilepsy comprising 5g of cannabis extract, 1 g of Tianma extract, 0.1g, manufactured by the following preparation method, including the steps of:

[0063] Step S1, prepare cannabis extract;

[0064] Step S2, prepare the generic extract;

[0065] Step S3, the prepared cannabis extract 5g, Tianma extract 1 g and 0.1 g of ice sheet, adding microcrystalline cellulose 12g mixed;

[0066] Step S4, the mixed uniform material is employed by 80% ethanol for pharmaceutical granulation, over 20 mesh screen, and then drying at a temperature of 40 ° C;

[0067] Step S5, over 16 mesh sieves, mixed with a particle weight of 1%, and mix well, and the tablets are obtained.

[0068] Wherein, step S1 includes the following steps:

[0069] Step S11, place the dry process hemp in the oven for drying treatment, drying for 4 hours at 80 ° C temperature conditions, drying it after drying, pulverizing the medicinal material dry powder, taking a dry powder 1kg spare o...

Embodiment 3

[0082] A drug for treating refractory epilepsy, including cannabis extract 12g, Tianma extract 4G and ice sheet 0.4g, manufactured by the following preparation method, including the following steps:

[0083] Step S1, prepare cannabis extract;

[0084] Step S2, prepare the generic extract;

[0085] Step S3, the prepared cannabis extract 12g, Tianma extract 4G and 0.4 g of the ice sheet and the microcrystalline cellulose 12g mixed;

[0086] Step S4, the mixed uniform material is employed by 80% ethanol for pharmaceutical granulation, over 20 mesh screen, and then drying at a temperature of 40 ° C;

[0087] Step S5, over 16 mesh sieves, mixed with a particle weight of 1%, and mix well, and the tablets are obtained.

[0088] Wherein, step S1 includes the following steps:

[0089] Step S11, place the dry process hemp in the oven for drying treatment, drying for 4 hours at 80 ° C temperature conditions, drying it after drying, pulverizing the medicinal material dry powder, taking a dry ...

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Abstract

The invention discloses a medicine for treating intractable epilepsy and a preparation method thereof, the medicine comprises a cannabis sativa extract, a gastrodia elata extract and borneol, the effective component of the cannabis sativa extract is a compound which is separated and extracted from cannabis sativa and has an alkylresorcinol structure, the medicine has a great synergistic effect on playing a pharmacological effect on intractable epilepsy, and the pharmacological activity of the pharmaceutical composition is effectively improved; the gastrodia elata extract can provide effective nutrition and repair nerves in the brain, the borneol can be used as a channel guiding drug to enhance absorption of other drugs in a blood brain barrier and effectively relieve convulsion, spasm, unconsciousness, wandering and other clinical characteristics accompanied by epilepsy disease attack, and the three drug components are subjected to traditional Chinese medicine prescription compatibility, and the intractable epilepsy is effectively treated in a targeted manner from three aspects of pathological treatment of epilepsy diseases, nutrition and repair of damaged nerves in the brain and relieving of clinical characterization.

Description

Technical field [0001] The present invention relates to the field of medical technology, and more particularly to drugs for the treatment of difficult epilepsy and preparation methods thereof. Background technique [0002] Epilepsy is one of the common serious brain dysfunction diseases that seriously endangered human health. Studies that the temporary central nervous system function caused by the abnormal discharge of brain neurons is its main cause, with sponality, transient, repeatability. And usually a syndrome characterized by a combined central nervous system functional disorder, and the seizures of patients with epilepsy can be controlled by drug treatment, but some patients have differences in the treatment of epilepsy, and epilepsy is difficult to control. Therefore, it is called difficult Intractable Epilepsy, also known as refractory epilepsy, and the treatment of refractory epilepsy is also known as the difficulty of treatment of epilepsy. [0003] Cannabis is a chemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P25/08A61K31/05A61K31/045
CPCA61K31/05A61K36/8988A61K31/045A61P25/08A61K2300/00
Inventor 王楠
Owner 黑龙江汉普康制药有限公司
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