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Anti-irritation composition and application thereof

A composition and anti-irritant technology, applied in the field of anti-irritant compositions, can solve the problem of not being able to ensure the safety of surfactants at the same time, and achieve the effects of reducing adverse skin reactions and reducing irritation

Active Publication Date: 2021-06-25
BEIJING ACAD OF TCM BEAUTY SUPPLEMENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods cannot guarantee the function and safety of the surfactant at the same time.

Method used

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  • Anti-irritation composition and application thereof
  • Anti-irritation composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1, anti-surfactant stimulates raw material screening

[0077] The present invention screens and extracts a variety of traditional Chinese medicine raw materials and compounds claiming to have anti-stimulation, and investigates the antagonism effect of each Chinese medicine extract on red blood cell stimulation caused by SDS through red blood cell hemolysis and coagulation test.

[0078] The present invention also investigated the antagonistic effects of different anionic polysaccharides and three competing products on the red blood cell stimulation caused by SDS.

[0079] Table 1 Sources of raw materials used

[0080]

[0081]

[0082] Market Competitor 1 Ingredients: Butylene Glycol, Water, Centella Asiatica (Centella Asiatica) Extract, Polygonum Cuspidatum Root Extract, Scutellaria Baicalensis Root Extract, Tea (Camellia Sinensis) Leaf Extract, Light Glycyrrhiza Glabra Root Extract, Chamomilla Recutita Flower Extract, Rosemary (Rosmarinus Officinalis...

Embodiment 2

[0119] Add 3 parts of peach gum and 1 part of cactus, add 50 parts of pure water, extract with pure water, extract at 70°C for 2 hours; centrifuge at 5000rpm for 10 minutes, take the supernatant; use a 50nm microfiltration membrane module to perform microfiltration and concentration, and remove the supernatant For substances with a middle molecular weight below 50wDa, retain the effluent to obtain a microfiltrate.

Embodiment 3

[0121] Add 10 parts of peach gum and 5 parts of cactus, add 100 parts of pure water, extract with pure water, extract at 80°C for 0.5h; centrifuge at 4000rpm for 30min, take the supernatant; use a 50nm microfiltration membrane module to perform microfiltration and concentration, and remove the supernatant Substances with a molecular weight below 50wDa in the liquid are retained to obtain a microfiltrate.

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Abstract

The invention relates to an anti-irritation composition and an application thereof. The anti-irritation composition comprises a peach gum extract and a cactus extract. The anti-irritation composition disclosed by the invention has a remarkable effect of antagonizing irritation of a surfactant. The efficacy evaluation experiments prove that the anti-irritation composition has an obvious inhibiting effect on erythrocyte hemolysis caused by the surfactant, the irritation to chick chorioallantoic membrane caused by the surfactant is obviously reduced, skin texture damage caused by the surfactant can be effectively improved, the skin lipid arrangement disorder caused by the surfactant is obviously improved, and the adverse reaction of different surfactants on the human skin is obviously reduced.

Description

technical field [0001] The invention relates to the field of daily cosmetics, in particular to an anti-irritant composition and its application. Background technique [0002] Surfactants have multiple functions such as dispersion, decontamination, solubilization and penetration, and are widely used in various detergents and cleaning compositions to impart their cleaning properties, and are an important part of cosmetics. Surfactants can be divided into ionic surfactants and nonionic surfactants according to the characteristics of molecular composition and the dissociation properties of polar groups. [0003] The irritation or sensitization of surfactants to the skin or mucous membranes is mainly reflected in three aspects: (1) Dissolution: the dissolution of surfactants on the skin's own moisturizing ingredients, intercellular lipids, and free amino acids and fats in the stratum corneum. Dissolution degree. Surfactants will affect the degree of dissolution of the skin's ow...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/73A61K8/44A61K8/60A61K8/41A61K8/86A61Q19/00A61Q5/02A61Q19/10A61Q5/12
CPCA61K8/9789A61K8/73A61K8/442A61K8/602A61K8/416A61K8/86A61K8/44A61Q19/00A61Q5/02A61Q19/10A61Q5/12A61K2800/596
Inventor 孟宏苏牧楠曲召辉刘有停刘宇红刘月恒
Owner BEIJING ACAD OF TCM BEAUTY SUPPLEMENTS
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