Construction method and device for cerebral apoplexy multi-gene genetic risk comprehensive score (metaPRS) and application
A genetic risk and comprehensive scoring technology, which is applied in the construction, device and application field of stroke polygenic genetic risk comprehensive scoring, can solve the problem that polygenic genetic risk scoring is not suitable for East Asian populations, etc.
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[0066] Study Design Process and Study Population
[0067] For the research design process, see figure 1 shown.
[0068] In this study, a case-control designed training set was used to construct metaPRS, and it was validated and validated in a large prospective cohort "Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR)". To evaluate its clinical value in stroke risk prediction.
[0069] The training set included 2872 stroke cases (2548 ischemic and 324 hemorrhagic strokes) and 2494 controls (Table 1). All cases had a valid diagnosis of stroke, confirmed by a neurologist based on medical records from computed tomography (CT) and / or magnetic resonance imaging (MRI). The control group consisted of individuals who participated in the community cardiovascular risk factor survey and who were stroke-free as determined by medical history, clinical examination, and standard questionnaires.
[0070] Table 1. Crowd characteristics of the training set
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