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Marker for predicting response of cancer patient to chemotherapy and application thereof

A chemotherapy response and marker technology, applied in the field of oncology, can solve the problems of low response rate and insufficient chemotherapy efficacy

Pending Publication Date: 2021-06-22
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, chemotherapy is underpowered, as response rates in most clinical trials are below 40%

Method used

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  • Marker for predicting response of cancer patient to chemotherapy and application thereof
  • Marker for predicting response of cancer patient to chemotherapy and application thereof
  • Marker for predicting response of cancer patient to chemotherapy and application thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0015] The present invention will be described in detail below in combination with specific embodiments.

[0016] The purpose of the present invention is to provide a marker and its application for predicting the response of cancer patients to chemotherapy.

[0017] Sample Collection

[0018] All tissues were collected from patients at the Cancer Institute and Hospital of the Chinese Academy of Medical Sciences. None of these patients had received antitumor therapy before chemotherapy. All tissue samples were bronchoscopically examined by an experienced physician and independently examined by two experienced pathologists. For 2D-DIGE, six pairs of pre-treatment fresh primary lung adenocarcinomas with different chemotherapy responses were obtained during 2007–2008 (Table 1). Necrotic tissue confirmed by histopathological evaluation was excluded. Immediately after excision, samples were snap frozen in liquid nitrogen and stored at -80°C until use. For immunohistochemical an...

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Abstract

The invention discloses a marker for predicting response of a cancer patient to chemotherapy. The marker is peroxidase 6. The sensitivity of the cancer patient to chemotherapy reaction is predicted through the marker, and the marker can be used for predicting chemotherapy reaction and guiding personalized treatment of the patient.

Description

technical field [0001] The present invention relates to the field of oncology, in particular to a marker and application for predicting the response of cancer patients to chemotherapy (chemotherapy). Background technique [0002] Lung cancer is the leading cause of cancer death in both men and women worldwide, accounting for more than one million deaths each year. Lung adenocarcinoma (AD) is the main type of non-small cell lung cancer (NSCLC), and its incidence has increased in recent years. Despite great progress in the treatment of the disease, especially new drugs targeting certain genes and the utilization of anti-PD-1 immunotherapy, platinum-based (cisplatin or carboplatin) doublet chemotherapy remains the standard drug of choice , conventional treatment of advanced NSCLC patients without sensitive EGFR mutations (NCCN guidelines; http: / / www.nccn.org / professionals / ) improves survival outcomes. Unfortunately, chemotherapy is underpowered, as response rates in most clin...

Claims

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Application Information

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IPC IPC(8): C12Q1/28
CPCC12Q1/28G01N2800/7028G01N2800/52
Inventor 高亦博李宝重
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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