Multi-channel switching circuit, switching method

Abstract

The embodiment of the present invention provides a multi-channel switching circuit and switching method, including: a multiplexing switch matrix, the control terminal of the multiplexing switch matrix is ​​connected to a controller; the multiplexing switch matrix includes a plurality of multiplexing Using a switch, each output channel of each multiplexing switch is respectively connected to a sensor circuit; the common end of each multiplexing switch is respectively connected to the first input end of the signal detection circuit; the output end of the signal detection circuit is connected to the control device, the second input end of the signal detection circuit is connected to the output end of the digital-to-analog converter DAC; the input end of the digital-to-analog converter DAC is connected to the controller; the controller is used to control the digital-to-analog conversion when the multiplexing switch switches the output channel The DAC adjusts the bias voltage applied to the input channel of the multiplexing switch according to a preset gradient function. According to the switching circuit of the embodiment of the present invention, the instantaneous current and voltage generated during channel switching can be reduced, thereby reducing the influence on adjacent channels.

Description

technical field [0001] The invention belongs to the field of gene sequencing, and in particular relates to a multi-channel switching circuit and a switching method. Background technique [0002] The nanopore array of the nanopore sequencer has hundreds or thousands of nanopores for gene sequencing. However, not all nanopores in a nanopore array remain usable after production or during sequencing. In order to improve data acquisition efficiency, reduce cost and save space, signal acquisition systems often group multiple nanopores into one group, and select the one with the best quality from the multiple nanopores for sequencing; therefore, during the sequencing process, Switch among multiple wells in real time based on the state of the wells. [0003] In common circuit design, multiplexing switches are often used to select a target channel from multiple input channels for subsequent signal processing. However, the application of multiplexing switches often does not conside...

AI Technical Summary

Problems solved by technology

However, the application of multiplexing switches often does not consider the crosstalk caused by the switching of the current channel to adjacent channels, and this crosstalk has a great influence on the results in the measurement of dense channels and weak signals

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