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Fusion protein and application thereof

A fusion protein and virus technology, applied in the field of biomedicine, can solve the problems of difficult development of vaccines, adverse effects, and vaccines that do not work as they should.

Pending Publication Date: 2021-06-15
VIVA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vaccine development is difficult, takes a long time, and the effect varies from person to person. Under special circumstances, the vaccine may not have the expected effect or even have the opposite effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The fusion protein ACE2-huFc(G1)-RNase7 of this example is used for nasal and eye drips to prevent new coronavirus infection. The fusion protein sequence is as follows:

[0028] STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWS

[0029] AFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQE

[0030] CLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVN

[0031] GVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYS

[0032] LTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS

[0033] IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEP

[0034] VPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRL

[0035] GKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD

[0036] QSIKVRISLKSALGD

[0037] RAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEV

[0038] EKAIRMSRSRINDAFRL...

Embodiment 2

[0050] The fusion protein ACE2-huFc(G1+M)-RNase7 of this example is used for nasal and eye drips to prevent new coronavirus infection. The fusion protein sequence is as follows:

[0051] STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWS

[0052] AFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQE

[0053] CLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVN

[0054] GVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYS

[0055] LTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS

[0056] IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEP

[0057] VPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRL

[0058] GKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD

[0059] QSIKVRISLKSALGD

[0060] RAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEV

[0061] EKAIRMSRSRINDAF...

Embodiment 3

[0075] The fusion protein ACE2m(H374D, H378D)-huFc(G1)-RNase7 of this example is used for nasal and eye drips to prevent new coronavirus infection or intravenous injection treatment. The fusion protein sequence is as follows: (H at position 374 in the ACE2 sequence, Modified to D, 378-bit H, also modified to D):

[0076] MSSSSWLLLSLVAVTAAQ (signal peptide)

[0077] STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWS

[0078] AFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQE

[0079] CLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVN

[0080] GVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYS

[0081] LTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHdEMGdIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS

[0082] IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEP

[0083] VPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRL

[0084] GKSEP...

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Abstract

The invention provides a fusion protein and application thereof. The fusion protein comprises nuclease, a virus antibody or a virus receptor. The fusion protein for preventing and treating viral infectious diseases is faster and easier to develop than vaccines, and has higher safety and effectiveness. The fusion protein can be popularized and applied to prevention and treatment of various virus infectious diseases.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to a fusion protein and its application. Background technique [0002] All viruses have nucleic acid (including DNA and RNA), and all use nucleic acid as the basis for parasitic survival. At present, the response to viral infectious diseases (such as new coronavirus, HIV, etc.) mainly relies on vaccines. Vaccine development is difficult, takes a long time, and the effect varies from person to person. Under special circumstances, the vaccine may not work as it should or even have the opposite effect. Therefore, it is necessary to develop a combined method for preventing and treating viral diseases mainly based on direct killing of viruses. [0003] In view of this, the present invention is proposed. Contents of the invention [0004] The key feature of this method is that through protein fusion (nuclease-virus recognition protein fusion) or carrier combination (nuclease-virus ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K19/00C12N9/22C12N9/48C12N15/62A61K9/00A61K38/46A61K47/64A61K47/68A61P31/14
CPCC12N9/22C07K16/10C07K14/70503C12N9/485C12Y304/17023A61K47/64A61K47/6425A61K47/6815A61K47/6841A61K9/0043A61K9/0048A61P31/14C07K2319/00C07K2319/30A61K38/00
Inventor 钱冬明任德林毛晨
Owner VIVA BIOTECH
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