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Tumor gene co-expression network construction method, device, equipment and storage medium

A network construction, tumor gene technology, applied in the field of equipment and storage media, tumor gene co-expression network construction method, device field, can solve the problem of unable to realize various cancer network data mining and so on

Active Publication Date: 2022-05-17
SHENZHEN POLYTECHNIC +1
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Problems solved by technology

[0004] In related technologies, when using corresponding algorithms and / or models to predict cancer markers, usually an algorithm and / or model can only perform simple predictions on the network construction of one type of cancer, but cannot realize the prediction of multiple cancers. web data mining

Method used

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  • Tumor gene co-expression network construction method, device, equipment and storage medium
  • Tumor gene co-expression network construction method, device, equipment and storage medium
  • Tumor gene co-expression network construction method, device, equipment and storage medium

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Embodiment Construction

[0054] In order to make the above objects, features and advantages of the present application more obvious and understandable, the present application will be further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0055] refer to figure 1 with figure 2, shows a flowchart of a method for constructing a tumor gene co-expression network in the present application. Such as figure 1 As shown, the method includes the following steps:

[0056] S101. Obtain the cancerous transcriptome sequencing data of various tissues in the target human body system and the normal transcriptome sequencing data of the various tissues; the target human body system is any one of the eight major human body systems in human anatomy.

[0057] From an anatomical point of view, there are eight major systems in the human body: motor system, nervous system, endocrine system, circulatory system, respiratory system, digestive system, urinary sys...

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Abstract

The present application provides a method, device, equipment and storage medium for constructing a tumor gene co-expression network. The method includes: acquiring the cancerous transcriptome sequencing data of various tissues in the target human body system and the normal transcriptome sequencing data of the various tissues; the target human body system is any one of the eight major human body systems of human anatomy ; According to the relationship between genes and transcripts, as well as RNAs with uniform gene expression in normal transcriptome sequencing data, differential mRNAs, lncRNAs and miRNAs are extracted from cancer transcriptome sequencing data of various tissues; Carcinogenic differential mRNA, lncRNA, and miRNA of various tissues were analyzed by GO, and a target expression matrix was obtained; the target expression matrix was analyzed by WGCNA, expression modules were constructed according to traits, and the most relevant modules were selected for network construction. It can realize network construction for various cancers.

Description

technical field [0001] The present application relates to the field of biological information technology, in particular to a method, device, equipment and storage medium for constructing a tumor gene co-expression network. Background technique [0002] Cancer is a disease caused by genetic or epigenetic canceration, specifically due to the mutation of proto-oncogene and tumor suppressor gene, the growth and division of normal cells are out of control and become cancer cells, and then manifested pathologically Cancer-related symptoms. The early human research method for cancer was to compare and analyze the genes and / or genome regions and proteins of cancer cells with the genes and / or genome regions of healthy cells and the proteins of cancer cells, so as to find the pathogenesis and treatment method. Although this early research method can screen out reliable cancer markers, it will consume a lot of time and financial resources during the experiment, which seems traditiona...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B5/00G16B25/00
CPCG16B5/00G16B25/00
Inventor 徐磊王彦苏邹权
Owner SHENZHEN POLYTECHNIC
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