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Acute myocardial infarction biomarker and application thereof

An acute myocardial infarction and application technology, applied in the field of acute myocardial infarction biomarkers, can solve the problems of no uniform standard, limited application, unclear sensitivity and specificity, etc., and achieve high specificity, good sensitivity and accurate diagnosis

Pending Publication Date: 2021-05-28
张步春
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As for the diagnostic method of the characteristic changes of the ECG, due to the lack of large-sample controlled clinical studies, the sensitivity and specificity of the ECG diagnostic criteria for AMI recommended by various authoritative organizations are not yet clear, and there is no unified standard, which limits its application.
The detection specificity and accuracy of a serum protein marker are unsatisfactory

Method used

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  • Acute myocardial infarction biomarker and application thereof
  • Acute myocardial infarction biomarker and application thereof
  • Acute myocardial infarction biomarker and application thereof

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Embodiment 1

[0064] Subject selection:

[0065] Inclusion criteria: 1) Inclusion criteria for patients with acute ST-segment elevation myocardial infarction (STEMI) refer to the 2012 version of the global unified definition of myocardial infarction: serum myocardial markers, mainly troponin, are elevated, at least exceeding the upper limit of 99% of the reference value, Accompanied by CAG or CCTA confirmed coronary thrombosis, one or more than one coronary artery trunk or branch stenosis, the degree is greater than 70%; ECG ST segment arch upward.

[0066] (2) Inclusion criteria for the healthy control group: the same gender as the experimental group, no coronary heart disease characteristics in the electrocardiogram, normal serum myocardial enzyme markers, mainly troponin, and no abnormal stenosis of the coronary artery lumen as shown by CAG or CCTA.

[0067] Exclusion criteria: ①Patients suffering from other heart diseases, such as rheumatic heart disease, valvular heart disease or conge...

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Abstract

The invention belongs to the field of myocardial infarction diagnosis research, and provides application of miR-532-5p and / or miR-766-5p in preparation of an acute myocardial infarction diagnosis product. According to the application disclosed by the invention, the fact that the miR-532-5p and / or the miR-766-5p from the serum exosome can be used as the diagnosis marker for diagnosing the acute myocardial infarction is found for the first time, and the miR-532-5p and / or the miR-766-5p from the serum exosome can be used as the marker for diagnosing the acute myocardial infarction or prognostically judging the acute myocardial infarction, so that the diagnosis of the acute myocardial infarction is more accurate and rapid, and the specificity is high and the sensitivity is good.

Description

technical field [0001] The invention belongs to the field of myocardial infarction diagnosis research, and in particular relates to acute myocardial infarction biomarkers and applications thereof. Background technique [0002] Acute myocardial infarction (AMI) is myocardial necrosis caused by acute and persistent coronary ischemia and hypoxia. Clinically, there are often severe and persistent substernal pains, which cannot be completely relieved by rest and nitrates, accompanied by increased serum myocardial enzyme activity and progressive ECG changes, which may be complicated by arrhythmia, shock or heart failure, often life-threatening. [0003] The methods for diagnosing acute myocardial infarction in the prior art include: (1) The characteristic changes of electrocardiogram are new Q wave and ST segment elevation and ST-T dynamic evolution; (2) Serum biomarkers of myocardial necrosis increase, muscle necrosis Acid kinase isoenzyme (CK-MB) and troponin (T or I) increased...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/178C12Q2600/118
Inventor 张步春马礼坤
Owner 张步春
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