Application of thickleaf croton root ethanol extract to preparation of medicine for relaxing preshrunk tracheal smooth muscle

A technique for tracheal smooth muscle and fragrant ethanol, which is applied in the field of medicine and can solve the problems such as chicken bone fragrant asthma and research reports on relaxation of tracheal smooth muscle, etc., and achieve the effect of efficiently relaxing tracheal smooth muscle.

Inactive Publication Date: 2021-05-07
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At present, there is no research report on the treatment of asthma and relaxation of tracheal smooth muscle with Jiguxiang

Method used

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  • Application of thickleaf croton root ethanol extract to preparation of medicine for relaxing preshrunk tracheal smooth muscle
  • Application of thickleaf croton root ethanol extract to preparation of medicine for relaxing preshrunk tracheal smooth muscle

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Embodiment Construction

[0015] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, and the content of the present invention is not limited to the following embodiments.

[0016] 1. The preparation of the extract of the ethanol part of Jiguxiang:

[0017] Grind 2 kg of the root of Ji Gu Xiang, weigh 1 kg of Ji Gu Xiang coarse powder, soak it in an ethanol solution with a volume concentration of 95% at room temperature, soak for 7 days, and have a solid-to-liquid ratio of 1:10. The filtrate is obtained by filtration, and the filtrate is rotary evaporated to obtain an ethanol extract, and the extracted ethanol part is placed in a vacuum drying oven for storage for later use. During the experiment, the ethanol extract of A. japonicus was dissolved in dimethyl sulfoxide (DMSO).

[0018] 2. Processing of Mouse Isolated Tracheal Rings

[0019] Eight-week-old male BABL / c mice were sacrificed by spine breaking method, and fixed on the dissec...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of a thickleaf croton root ethanol extract to preparation of a medicine for relaxing preshrunk tracheal smooth muscle. According to the invention, test on in-vitro tracheal ring muscle tension of an experimental mouse discovers that the thickleaf croton root ethanol extract has the effective effect for relaxing tracheal smooth muscle, and the thickleaf croton root ethanol extract is expected to be used for relieving asthma. A basis is provided for developing the application of the thickleaf croton root ethanol extract to preparation of the medicine for relaxing preshrunk tracheal smooth muscle.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of the ethanol part extract of Jiguxiang in the preparation of medicine for relaxing and pre-contracting tracheal smooth muscle. Background technique [0002] Asthma, the full name of bronchial asthma, is a common chronic airway inflammation. The pathogenesis of asthma is complex, related to many factors and varies from person to person. Asthma patients may have symptoms such as wheezing, chest tightness, coughing, etc., and severe cases may even have difficulty breathing. In recent years, due to the deterioration of the environment, the incidence of asthma has continued to increase worldwide. Traditional Chinese medicine has a long history of treating asthma. Starting from this aspect, modern scientific and technological research is used to find reliable and effective Chinese medicine for treating and alleviating asthma. [0003] Chicken bone fragrance is bi...

Claims

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Application Information

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IPC IPC(8): A61K36/47A61P11/06
CPCA61K36/47A61P11/06A61K2236/333
Inventor 沈金花姚凤杰
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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