Application of m5c modification regulating genome in preparation of tumor prognosis assessment reagent or kit
A prognostic assessment and kit technology, which is applied in the field of medical biological detection, can solve the problems of little understanding of the role and mechanism of immunotherapy efficacy assessment, and achieve the effects of high repeatability, sensitive detection and easy operation.
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[0044] The present invention will now be described in detail with reference to the embodiments and accompanying drawings, but the implementation of the present invention is not limited thereto.
[0045] 1. Data preprocessing
[0046] 1. Download TCGA LUAD SNV data (MuTect2 Annotation) for a total of 570 samples.
[0047] 2. Download the TCGA LUAD CNV data for a total of 544 samples, use the hg38 reference group-based re-annotation through bedtools software, and extract the annotation results of 13 gene CNVs.
[0048] 3. Download the TCGA LUAD FPKM, and convert it into TPM data through further processing, a total of 572 samples and a total of 513 cases of clinical data on the follow-up time and follow-up status of patients. Among them, 513 were tumor samples and 59 were normal samples.
[0049] 4. Download the expression profile data (246 samples) of GSE31210 in the NCBI GEO database and the clinical data of the patient's follow-up time and follow-up status, a total of 246 sa...
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