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Tellurium-containing compound, method for preparing tellurium-gold nanoparticles by using tellurium-containing compound and application of tellurium-gold nanoparticles in preparation of anti-tumor drugs

A tellurium compound, HO-EGY- technology, applied in the field of nano-biomedicine, can solve the problems of complicated synthesis steps, high price, toxic and side effects, etc.

Active Publication Date: 2021-04-27
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of nanomedicine has the disadvantages of complex material structure and cumbersome synthesis steps, and it is difficult to achieve effective economic benefits through industrial production.
At the same time, while killing tumor cells, such nano-medicines also have relatively large toxic and side effects on normal cells, requiring surface modification to target small molecules or specific proteins to achieve selective treatment, which will lead to the clinical application of such drugs There are problems with high prices and harsh storage conditions

Method used

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  • Tellurium-containing compound, method for preparing tellurium-gold nanoparticles by using tellurium-containing compound and application of tellurium-gold nanoparticles in preparation of anti-tumor drugs
  • Tellurium-containing compound, method for preparing tellurium-gold nanoparticles by using tellurium-containing compound and application of tellurium-gold nanoparticles in preparation of anti-tumor drugs
  • Tellurium-containing compound, method for preparing tellurium-gold nanoparticles by using tellurium-containing compound and application of tellurium-gold nanoparticles in preparation of anti-tumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: Based on HO-EG 6 -C 6 -Te-C 6 -EG 6 Preparation of gold tellurium nanoparticles of -OH (bis(17-hydroxy-3,6,9,12,15-pentaoxoacetyl) 4,4'-telluryl dihexanoate) and chloroauric acid and its preparation Application in antineoplastic drugs

[0054] (1) 88.7mg HO-EG 6 -C 6 -Te-C 6 -EG 6 -OH was dissolved in 1 mL of deionized water to obtain component A, and 9.6 mg of chloroauric acid was dissolved in 1 mL of deionized water to obtain component B. Fully mix component A and component B in a 5mL reaction bottle to obtain a uniform mixed system. The above mixed system was lyophilized, rinsed three times with 2 mL of dichloromethane, and dried with nitrogen to obtain gold tellurium nanoparticles. where HO-EG 6 -C 6 -Te-C 6 -EG 6 The synthesis process of -OH molecule is as follows:

[0055] Dissolve 5.64g of hexaethylene glycol in a round-bottomed flask containing 100mL of dichloromethane, and add 4.27g of 6-bromohexanoyl chloride dropwise to the round-b...

Embodiment 2

[0065] Embodiment 2: Based on HO-EG 4 -C 6 -Te-C 6 -EG 4 Tellurium of -OH (bis(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl) 4,4'-telluryl dihexanoate) with chloroauric acid Preparation of gold nanoparticles and its application in the preparation of antitumor drugs

[0066] The difference between this embodiment and Example 1 lies in the preparation of gold tellurium nanoparticles, and all the other steps are the same as in Example 1, specifically:

[0067] 142.0mg HO-EG 4 -C 6 -Te-C 6 -EG 4 -OH was dissolved in 1 mL of ethylene glycol to obtain component A, and 2.6 mg of chloroauric acid was dissolved in 1 mL of dimethyl sulfoxide to obtain component B. Fully mix component A and component B in a 5mL reaction bottle to obtain a uniform mixed system. The above mixed system was dried in a vacuum oven, rinsed three times with 2 mL of tetrahydrofuran, and dried in a vacuum oven to obtain gold tellurium nanoparticles. where HO-EG 4 -C 6 -Te-C 6 -EG 4 The synthesis proce...

Embodiment 3

[0069] Embodiment 3: Based on HO-EG 2 -C 6 -Te-C 6 -EG 2 Preparation of tellurium gold nanoparticles of -OH (bis(2-(2-hydroxyethoxy)ethyl) 6,6'-telluryl dihexanoate) and chloroauric acid and its application in the preparation of antitumor drugs

[0070] The difference between this embodiment and Example 1 lies in the preparation of gold tellurium nanoparticles, and all the other steps are the same as in Example 1, specifically:

[0071] 17.8mg HO-EG 2 -C 6 -Te-C 6 -EG 2 -OH was dissolved in 1 mL of methanol to obtain component A, and 2.0 mg of gold chloride was dissolved in 1 mL of deethylene glycol to obtain component B. Fully mix component A and component B in a 5mL reaction bottle to obtain a uniform mixed system. The above mixed system was dried in a vacuum oven to remove the solvent, rinsed three times with 2 mL of ethyl acetate, and dried with nitrogen to obtain gold tellurium nanoparticles. where HO-EG 2 -C 6 -Te-C 6 -EG 2 The synthesis process of -OH molec...

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Abstract

The invention discloses a tellurium-containing compound, a method for preparing tellurium-gold nanoparticles by using the tellurium-containing compound and application of the tellurium-gold nanoparticles in preparation of anti-tumor drugs. According to the method, the tellurium-gold nanoparticles are prepared from a tellurium compound and a chloride ion complex of gold, and the nanoparticles can realize stimulation response under the action of an oxidizing agent. When the tellurium-gold nanoparticles and tumor cells are co-incubated, the cell survival rate can be observed to be remarkably reduced. When the tellurium-gold nanoparticles are co-incubated with normal cells, the survival state of the cells is good. Based on reducibility and coordination interaction of the tellurium element, the tellurium-containing compound serves as a reducing agent and a stabilizing agent at the same time, and tellurium-gold nanoparticles are prepared through different material synthesis methods while the molecular structure of the tellurium compound is regulated and controlled. The prepared material has oxidation stimulation responsiveness, is a potential selective anti-tumor drug, and has a good clinical application prospect.

Description

technical field [0001] The invention relates to the field of nano-biomedicine, in particular to a tellurium-containing compound, a method for preparing tellurium gold nanoparticles by using the tellurium gold nanoparticles, and an application of the tellurium gold nanoparticles in antitumor drugs. Background technique [0002] Cancer is one of the common malignant diseases. Because of its rapid development, low cure rate, and high recurrence rate, it causes serious economic and psychological burdens on patients. [0003] The +4-valent tellurium-containing functional structure has potential anti-tumor activity. This type of compound can induce cell apoptosis by inhibiting the active site of the selenol structure in the cell and disrupting the redox balance in the cell. AS101 is a +4-valent tellurium-containing molecule that entered Phase II clinical trials, however, due to its low stability and poor selectivity, further clinical trials could not be achieved. Solving the defe...

Claims

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Application Information

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IPC IPC(8): C07C395/00C01B19/00A61K33/242A61P35/00A61K33/04
CPCA61K33/04A61P35/00A61K33/242C01B19/007C07C395/00A61K2300/00
Inventor 许华平戴以恒李天予
Owner TSINGHUA UNIV
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