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Visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and preparation method thereof

A healing hydrogel and photocatalytic technology, applied in medical science, bandages, etc., can solve the problems of tissue damage, no reduction in infection, etc., achieve the effect of simple method, reduce bacterial infection, and promote wound healing

Pending Publication Date: 2021-04-16
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional medical dressings, such as absorbent cotton gauze, gauze strips, cotton balls, and cotton membranes, are clinically used to protect wounds and have the function of physical isolation, but they must be replaced regularly, and frequent excision may cause more tissue damage
Furthermore, they generally do not have the ability to reduce infection

Method used

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  • Visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and preparation method thereof
  • Visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and preparation method thereof
  • Visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh 20 mg of collagen and dissolve it in 2 mL of 1% acetic acid solution, stir well to dissolve it, and then adjust the pH to neutral with 1M sodium hydroxide solution to obtain a collagen solution. Weigh 40 mg of sodium alginate and dissolve it in 2 mL of deionized water, stir well to dissolve it, and obtain a sodium alginate solution. Add the sodium alginate solution into the collagen solution under stirring condition, and stir thoroughly to obtain the collagen-sodium alginate solution. Disperse graphite-phase carbon nitride nanosheets in deionized water, and ultrasonically treat for 30 minutes to obtain a uniform 0.6mg / mL graphite-phase carbon nitride nanosheet dispersion. Mix 1mL carbon nitride nanosheet dispersion with collagen-sodium alginate Mix the solution (the amount of graphite phase carbon nitride nanosheets is 1% of the total mass of collagen and sodium alginate), stir at room temperature for 2 hours, centrifuge to remove air bubbles, pour into a mold, le...

Embodiment 2

[0037] Weigh 20 mg of collagen and dissolve it in 2 mL of 1% acetic acid solution, stir well to dissolve it, and then adjust the pH to neutral with 1M sodium hydroxide solution to obtain a collagen solution. Weigh 40 mg of sodium alginate and dissolve it in 2 mL of deionized water, stir well to dissolve it, and obtain a sodium alginate solution. Add the sodium alginate solution into the collagen solution under stirring condition, and stir thoroughly to obtain the collagen-sodium alginate solution. Disperse graphite-phase carbon nitride nanosheets in deionized water and ultrasonically treat them for 30 minutes to obtain a uniform 1.2mg / mL graphite-phase carbon nitride nanosheet dispersion. Mix 1mL carbon nitride nanosheet dispersion with collagen-sodium alginate The solution was mixed (the amount of graphite phase carbon nitride nanosheets was 2% of the total mass of collagen and sodium alginate), stirred at room temperature for 2 hours, centrifuged to remove air bubbles, poure...

Embodiment 3

[0039] Weigh 20 mg of collagen and dissolve it in 2 mL of 1% acetic acid solution, stir well to dissolve it, and then adjust the pH to neutral with 1M sodium hydroxide solution to obtain a collagen solution. Weigh 40 mg of sodium alginate and dissolve it in 2 mL of deionized water, stir well to dissolve it, and obtain a sodium alginate solution. Add the sodium alginate solution into the collagen solution under the condition of stirring, and stir thoroughly to obtain the collagen-sodium alginate solution. Disperse graphite-phase carbon nitride nanosheets in deionized water and ultrasonically treat them for 30 minutes to obtain a uniform 1.8mg / mL graphite-phase carbon nitride nanosheet dispersion. Mix 1mL carbon nitride nanosheet dispersion with collagen-sodium alginate The solution was mixed (the amount of graphite phase carbon nitride nanosheets was 3% of the total mass of collagen and sodium alginate), stirred at room temperature for 2 hours, centrifuged to remove air bubbles...

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Abstract

The invention discloses visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: preparing bulk-phase graphite-phase carbon nitride by taking melamine as a raw material, and stripping the bulk-phase graphite-phase carbon nitride into ultrathin carbon nitride nanosheets by adopting acid etching and ultrasonic treatment; then mixing the prepared carbon nitride nanosheet dispersion liquid with a collagen sodium alginate solution to obtain a gel precursor; and crosslinking the gel precursor by using a calcium chloride solution to obtain the visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel. The hydrogel prepared by the preparation method not only has an excellent photocatalytic antibacterial effect in response to visible light, but also has good biocompatibility and swelling property, and can absorb redundant tissue fluid to provide a wet environment for wound repair, so that the effect of promoting wound healing is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a visible light-responsive photocatalytic antibacterial and healing-promoting hydrogel and a preparation method thereof. Background technique [0002] Wound healing is often accompanied by bacterial infection, which usually requires treatment with antibiotics. However, overuse of antibiotics can lead to the development of drug resistance and superbugs, which can also lead to side effects that damage the immune system. Although some inorganic antibacterial drugs and organic antibacterial agents have broad-spectrum antibacterial ability, most of them are toxic in vivo and act slowly. [0003] The main function of medical dressings is to cover and protect damaged skin and provide an environment conducive to wound healing. Traditional medical dressings, such as absorbent cotton gauze, gauze strips, cotton balls, and cotton membranes, are clinically used to ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24A61L26/00C08L5/04C08L89/00C08K3/28
Inventor 陈敬华张慧杰叶宝婷
Owner JIANGNAN UNIV
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