Construction method of animal ureteral calculus model

Abstract

The invention discloses a construction method of an animal ureteral calculus model. The method comprises the following steps of selecting a white rabbit, and performing ear vein injection by using a urethane solution; enabling the rabbit to be on an operating table with the supine position, enabling the lower left abdomen to be subjected to hair scraping, disinfecting the skin through iodophor, performing incision on the left side of the middle of the abdomen, and entering the abdominal cavity layer by layer; after entering the abdominal cavity, dissociating the paracolic sulci at the left side, pushing open the descending colon and the mesostenium to expose the ureter at the left side, injecting flowing resin into the upper end of the dissociating ureter by using an injector, and irradiating and fixing by using a photocuring lamp; resetting the colon at the left side and the mesostenium after no urine leakage occurs, closing the abdominal cavity layer by layer, disinfecting the woundwith iodophor, and covering the wound with gauze; and three days after the operation, performing penicillin U intramuscular injection every day. According to the animal ureteral calculus model constructed by the method, the flowing resin material has the characteristics of short solidification time, small damage to smooth muscle tissues and the like, and the model has the advantages of good calculus forming effect, short calculus forming time, economy, timeliness, reproducibility, high controllability and the like.

Description

technical field [0001] The invention relates to a method for constructing an animal ureter calculus model, and belongs to the technical field of ureter calculus models. Background technique [0002] Urinary calculus is one of the common diseases in urology, occupying the first place among inpatients in urology. In recent years, the incidence of urinary stones in my country has been increasing, and it is one of the three high-incidence areas of stones in the world. More than 70% of patients with urinary stones will have stone recurrence after treatment, and the recurrence rate increases with the passage of time after surgery. And increase. Animal calculus models play an important role in the process of studying the mechanism of calculus occurrence and development. At present, the methods for constructing animal models mainly include calcium oxalate precursor method, surgical operation, etc., which are not only helpful for the study of disease mechanism, but also for Screenin...

AI Technical Summary

Problems solved by technology

[0005] The etiology and mechanism of ureteral calculi are complex, but currently known methods of constructing animal models of ureteral calculi are mostly kidney and bladder calculi, and there is no method that can form stable calculi in the ureter

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