Streptococcus thermophilus and application thereof

Abstract

The invention discloses a streptococcus thermophilus and an application thereof, the streptococcus thermophilus is screened from farmhouse self-made yoghourt, and the streptococcus thermophilus has extremely strong capacity of relieving inflammatory reaction, and does not have risk genes such as plasmids and transfer elements; the streptococcus thermophilus has a strong inhibition capability on macrophage inflammatory reaction caused by LPS; the streptococcus thermophilus has strong protection capability on organ injuries caused by sepsis models constructed by CLP and LPS, can relieve inflammatory reaction of patients with sepsis, and is beneficial to development of medicines for relieving sepsis related symptoms.

Description

technical field [0001] The invention relates to a strain of streptococcus thermophilus and its application, and belongs to the field of bacteria and its cultivation. Background technique [0002] Sepsis and its related diseases are one of the main causes of human death. It is caused by an imbalanced host response to infection, often accompanied by acute organ dysfunction and high risk of death. The outbreak of inflammatory response is one of its pathogenesis. First, many studies have shown that the inflammatory response is closely related to the intestinal flora. At the same time, many studies have proved that probiotics can improve the inflammatory response by affecting the composition of the intestinal flora and achieve the purpose of treating inflammatory diseases. At the same time, patients with sepsis often suffer from malnutrition due to difficulty in eating, which leads to other systemic diseases. [0003] The current treatment for patients with sepsis mainly focuses...

AI Technical Summary

Problems solved by technology

There are many problems in antibiotic drug treatment: First, antibiotics kill pathogenic bacteria and eliminate inflammation while inhibiting the growth of probiotics and reducing the abundance of probiotics, which is very unfavorable for the maintenance of intestinal flora in patients with sepsis. , which greatly increases the risk of repeated infection and recurrence; second, taking drugs cannot achieve the purpose of precise treatment, and can only act on a broad-spectrum systemic range, which is especially easy to damage liver and kidney functions, which has already damaged sepsis patients themselves. Undoubtedly, the liver and kidney functions are more of a burden; third, frequent use of antibiotics can easily lead to drug resistance of pathogenic bacteria, which is also an important reason for secondary infections. At the same time, a large number of sepsis patients do not have suitable antibiotics Use, which in turn leads to an exacerbated inflammatory response, which in turn causes a systemic inflammatory response

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