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Application of marine phospholipid as effective component in preparation of medicine for preventing and/or treating heart diseases

A heart disease and active ingredient technology, applied in the field of medicine, can solve the problems of liver toxicity and the urgent need for heart disease drugs, and achieve the effect of promoting cardiac expansion, reducing congestion and protecting the heart.

Active Publication Date: 2021-03-16
BIOLOGY INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, drugs for the treatment of heart disease have safety problems such as hepatotoxicity, and there is an urgent need to develop safe and effective drugs for heart disease

Method used

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  • Application of marine phospholipid as effective component in preparation of medicine for preventing and/or treating heart diseases
  • Application of marine phospholipid as effective component in preparation of medicine for preventing and/or treating heart diseases
  • Application of marine phospholipid as effective component in preparation of medicine for preventing and/or treating heart diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1. Preparation of Phospholipid Fractions

[0054] Shrimp heads of 200g Penaeus vannamei were homogenized and crushed with a homogenizer, and 95% ethanol with a concentration of 8 times the volume of raw materials was added to stir and extract twice, each time for 6 hours, the extract was mixed twice, and evaporated to dryness with a rotary evaporator Obtain ethanol extract of shrimp head.

[0055] The above-mentioned ethanol extract is first dissolved with a scavenger, and the scavenger is that the mass fraction is 1% CaCl 2 The solution was prepared by mixing the solution with absolute ethanol at a volume ratio of 1:20, and then extracted twice with n-hexane of 4 times the amount of purifying agent, evaporated the extract of the n-hexane layer to dryness and weighed the dried product, and mixed the dried product with n-hexane into a 0.5g / mL solution, then add acetone 10 times the amount of n-hexane and precipitate twice at -18°C, each time for 12 hours, centrifuge the...

Embodiment 2

[0062] Effects of phospholipid fractions from Penaeus vannamei on thrombus, heart failure and arrhythmia in zebrafish.

[0063] 1. Experimental animals

[0064] The animals used in the anti-thrombotic experiment and the anti-heart failure experiment of the present invention are all AB wild-type zebrafish, and the animals used in the arrhythmia experiment are heart fluorescent transgenic Tg (cmlc2:GFP) line zebrafish. They were reared under the conditions of 28°C, dark / illumination (10h:14h) photoperiod, and brine shrimp were fed regularly and quantitatively every day. When releasing fish for mating, take healthy and mature male and female zebrafish at a ratio of 1:2 to obtain fertilized eggs. 1hpf (hours post fertilization) collect the embryos, and wash the fertilized eggs with fish culture water. AB wild-type zebrafish embryos developed to 3dpf (days post-fertilization) were used for antithrombotic experiments, AB wild-type zebrafish embryos developed to 48hpf were used for...

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Abstract

The invention relates to application of marine phospholipid as an effective component in preparation of a medicine for preventing and / or treating heart diseases. The marine phospholipid is separated to obtain five phospholipid components comprising phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine and sphingomyelin. It is found that the components have good protection and treatment effects on the heart; and the phospholipid components have a remarkable heart protection effect on arachidonic acid-induced zebra fish thrombus, verapamil-induced zebra fish heart failure and terfenadine-induced zebra fish arrhythmia, and can obviously reduce zebra fish congestion and cardiac dilatation and promote heart rate to tend to be normal.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of marine phospholipids as active ingredients in the preparation of drugs for preventing and / or treating heart diseases. Background technique [0002] Heart disease is a common disease with the characteristics of "high morbidity, high disability rate, high mortality rate, high recurrence rate, and many complications", which seriously threatens human health. In recent years, the age of onset of heart disease tends to be younger. At present, drugs for the treatment of heart disease have safety problems such as liver toxicity, and there is an urgent need to develop safe and effective drugs for heart disease. [0003] Zebrafish is an important model organism for early rapid screening and target localization in drug discovery for cardiac diseases. Zebrafish has a high degree of similarity to human genes, has most of the tissues and organs of vertebrates, and has s...

Claims

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Application Information

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IPC IPC(8): A61K31/683A61K31/685A61K31/688A61K35/612A61P9/00A61P9/04A61P9/06A61P7/02
CPCA61K31/683A61K31/685A61K31/688A61K35/612A61P9/00A61P9/04A61P9/06A61P7/02
Inventor 张梦启李晓彬刘可春白树金李培海张姗姗张轩铭王利振张云
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI
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