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Apostichopus japonicus and sea cucumber flower lipid extract as well as preparation method and application thereof

A technology for extracting and sea cucumber is applied in the field of medicine to achieve the effects of good activity, significant regulation of blood lipid activity and high yield

Pending Publication Date: 2021-03-09
烟台东宇海珍品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Sea cucumber flower fat is a kind of fatty acid lipid extract extracted from sea cucumber flowers of sea cucumber, and there are few reports on its research

Method used

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  • Apostichopus japonicus and sea cucumber flower lipid extract as well as preparation method and application thereof
  • Apostichopus japonicus and sea cucumber flower lipid extract as well as preparation method and application thereof
  • Apostichopus japonicus and sea cucumber flower lipid extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Freshly collected sea cucumber flowers are washed with water and freeze-dried to obtain dried sea cucumber flower powder. Take 1000 grams of sea cucumber pollen, add 5 times the amount of 95% ethanol (V / V) each time, stir and extract 3 times, each time for 1 hour, centrifuge and filter, combine the extracts, recover the ethanol under reduced pressure to obtain a fluid extract, dissolve in 80% Add ethanol (V / V), add activated carbon, heat and reflux for 1 hour to decolorize, filter, recover the filtrate under reduced pressure, extract with dichloromethane, wash the extract with water 4 times, recover under reduced pressure to dryness, and obtain the brown oily sea cucumber flower lipid extraction The product is 72 grams, and the yield is about 7%.

[0019] Identification of sea cucumber flower lipid extract (hereinafter referred to as sea cucumber flower lipid):

[0020] In this study, the fatty acids in sea cucumber flower fat were treated with methyl esterification, a...

Embodiment 2

[0028] Embodiment 2. Sea cucumber flower fat regulates blood lipid experiment:

[0029] 1. Purpose of the experiment

[0030] To understand whether the test product sea cucumber flower fat has the effect of preventing hyperlipidemia in rats.

[0031] 2. Experimental materials

[0032] 2.1. Test drugs

[0033] Name or code: sea cucumber flower fat (code: HSZ-1)

[0034] Source: Provided by Professor Yi Yanghua;

[0035] Properties: brown oily substance;

[0036] Specifications: 50g;

[0037] Batch number: 20200418

[0038] Storage conditions: 4°C;

[0039] Validity: 2 years

[0040] Preparation method: Add 0.5% CMC-Na to suspend after homogenizer grinding.

[0041] 2.2. Positive control substance

[0042] Name or code: Atorvastatin Calcium Tablets;

[0043] Source: Xing'an Pharmaceutical Co., Ltd.;

[0044] Appearance: white flake;

[0045] Specification: 10mg;

[0046] Batch number: 042004071;

[0047] Storage conditions: sealed, stored in a cool place;

[0048...

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Abstract

The invention provides an apostichopus japonicus and sea cucumber flower lipid extract as well as a preparation method and application thereof. The sea cucumber flower lipid extract mainly contains 20fatty acids such as eicosapentaenoic acid and docosahexaenoic acid and the like, wherein 13 unsaturated fatty acids are contained, and the relative percentage content is not less than 70%. The extracted and purified sea cucumber flower lipid extract is administrated orally, so that the total cholesterol and low-density lipoprotein of hyperlipidaemia rats can be remarkably reduced, and the effectis close to that of a positive control drug atorvastatin calcium tablet. The extracted and purified sea cucumber flower lipid extract has a remarkable effect of reducing triglyceride in serum of the hyperlipidaemia rats, the effect of reducing triglyceride is superior to that of a positive control medicine atorvastatin calcium tablet, and meanwhile, the extracted and purified sea cucumber flower lipid extract has an obvious effect of increasing high-density lipoprotein of the hyperlipidaemia rats. The sea cucumber flower lipid extract has more remarkable blood fat regulating activity than seacucumber flowers, the effect of the sea cucumber flower lipid extract is far better than that of the sea cucumber flowers, and it is prompted that the sea cucumber flower lipid extract can be appliedto research and development of hyperlipidemia regulating drugs or health-care functional foods.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a sea cucumber imitation sea cucumber flower lipid extract and a preparation method and application thereof. Background technique [0002] Apostichopus japonicus Selenka, also known as Liaoshen, belongs to the genus Apostichopus of the family Apostichopaceae. It is mainly produced in coastal areas such as Shandong, Liaoning, Hebei, and northern Jiangsu in my country. Sea cucumber is listed as a tonic drug in "Compendium of Materia Medica", which says it "tonifies the kidney meridian, benefits the essence, eliminates phlegm and salivation, relieves urination, strengthens yang, and treats ulcer and gangrene." Those with thorns are called sea cucumbers, and those without thorns are called light ginseng." The sea cucumber flower is the intestinal egg part of the sea cucumber. After the sea cucumber is caught, it is generally dissected immediately to remove the viscera. A long kni...

Claims

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Application Information

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IPC IPC(8): A61K35/616A61P3/06A23L17/00A23L33/12
CPCA61K35/616A61P3/06A23L17/00A23L33/12A23V2002/00A23V2200/3262A23V2250/186
Inventor 易杨华李效平李铁鹏刘子元
Owner 烟台东宇海珍品有限公司
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