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Metal complex and preparation method thereof

A metal complex, C1-C20 technology, applied in chemical instruments and methods, compounds containing elements of group 8/9/10/18 of the periodic table, organic chemistry, etc., to simplify the operation process, broaden the coordination, reduce The effect of production costs

Pending Publication Date: 2021-03-02
SHENZHEN BAY LAB PINGSHAN TRANSLATIONAL MEDICINE CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of this application is to provide a metal complex and its preparation method, aiming to solve the technical problem of how to realize the complexation of chiral phosphorus-sulfur compounds and metals

Method used

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  • Metal complex and preparation method thereof
  • Metal complex and preparation method thereof
  • Metal complex and preparation method thereof

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preparation example Construction

[0090] On the other hand, in the preparation method of the metal complex described above, the preparation method comprises the following steps:

[0091] S01: Provide chiral β-nitrophosphorus sulfur compound A and carboxylic acid compound B;

[0092] S02: adding the chiral β-nitrophosphorus-sulfur compound A into a reaction system containing reducing metal, hydrochloric acid or trimethylchlorosilane for reaction to obtain a chiral β-aminophosphorus-sulfur compound C;

[0093] S03: adding the chiral β-aminophosphorous sulfur compound C into a reaction system containing the carboxylic acid compound B, a condensing agent, and an alkaline reagent to react to obtain a chiral β-aminophosphorous sulfur compound ligand D;

[0094] S04: Add the chiral β-amino acid phosphorous sulfur compound ligand D to the metal compound MR 6 react in the reaction system to obtain the metal complex shown in formula I;

[0095] The structural general formula of above-mentioned compound is as follows: ...

Embodiment 1

[0115] Provide nitrophosphorus-sulfur compounds A1 and carboxylic acid compounds B1 represented by the following structural formulas to prepare complexes of chiral phosphorus-sulfur compounds and metal complexes:

[0116] A1, B1,

[0117] (1) Preparation of β-aminophosphorus sulfur compound

[0118] Dissolve the above-mentioned nitrophosphorous sulfur compound A1 (0.1mmol) and zinc powder (0.7mmol) in a mixed solvent of 0.6mL methanol, 0.3ml tetrahydrofuran and 0.6ml hydrochloric acid (6M), heat to reflux at 80°C, and stir overnight. Detect the progress of the reaction with TLC, when the reaction is complete, slowly add saturated aqueous sodium bicarbonate solution dropwise, adjust the pH value of the solution to 8, filter with diatomaceous earth and extract twice with dichloromethane, and use the combined organic phase After drying with anhydrous sodium sulfate for 1 hour, filter, concentrate the organic phase and use silica gel column chromatography for direct separati...

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Abstract

The invention belongs to the technical field of organic synthetic chemistry, and particularly relates to a metal complex and a preparation method thereof. The general molecular structural formula of the metal complex is shown as formula I in the specification. The metal complex is a complex formed by complexing a chiral phosphorus-sulfur compound and metal, has a typical high-functionalization structure, such as a chiral quaternary carbon atom containing an electron withdrawing group and an amino group, not only has a classical organic metal complex structure, but also widens the coordinationof the phosphorus-sulfur compound, can expand organic asymmetric catalytic reaction, and has good application in synthesis of drug intermediates and preparation of functional materials.

Description

technical field [0001] The application belongs to the technical field of organic synthesis chemistry, and in particular relates to a metal complex and a preparation method thereof. Background technique [0002] Complexes with bidentate or tridentate clamp-like ligand scaffolds have attracted interest due to their wide application in organometallic complexes. After the discovery of the first cases of asymmetric synthesis applications, among these compounds, chiral derivatives have received great attention, and they have a wide range of applications in the fields of organic synthetic chemistry, biochemistry, asymmetric catalysis, pesticides, and pharmaceutical research. Application prospect. [0003] Metal complexes, especially chiral cyclopalladium complexes, have been mainly used in cycloaddition and hydrogenation functionalization reactions in the past decade. These synthetically challenging bisphosphorus and phosphorus-nitrogen bidentate ligands can form five- or six-mem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00
CPCC07F15/0066
Inventor 黄湧陈杰安李恩
Owner SHENZHEN BAY LAB PINGSHAN TRANSLATIONAL MEDICINE CENT
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