Application of a combined preparation of mesenchymal stem cell and exosome in preparation of myocardial infarction drug

Abstract

The invention provides application of a combined preparation of mesenchymal stem cell and exosome in preparation of myocardial infarction drug. The combined preparation of mesenchymal stem cell and exosome comprises mesenchymal stem cells and exosomes. The mesenchymal stem cells can secrete a large number of exosomes in the culture process, the exosomes secreted by the mesenchymal stem cells can adjust the local tissue microenvironment, promote angiogenesis, improve local blood supply, recover the thickness of the ventricular wall and improve the left ventricular ejection fraction of a myocardial infarction rat, and therefore the cardiac function of the rat is improved. The mesenchymal stem cells have a certain myocardial infarction treatment effect, the exosome suspension can provide a better living environment for the mesenchymal stem cells, and can maintain the activity and function of cells to the maximum extent.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of a combined preparation of mesenchymal stem cells and exosomes in the preparation of myocardial infarction drugs. Background technique [0002] Myocardial infarction is myocardial necrosis caused by acute and persistent coronary hypoxia. Clinically, there are often severe and persistent substernal pain, which cannot be completely relieved by rest and nitrates, accompanied by increased serum myocardial enzyme activity and progressive ECG changes, which may be complicated by arrhythmia, shock or heart failure. Acute myocardial infarction is a major disease that endangers human health. It is regarded as the "number one killer" in developed countries and is one of the leading causes of death worldwide. The increase in the incidence of AMI has brought heavy burdens to individuals, families, and society. Controlling the incidence of AMI and improving ...

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Problems solved by technology

[0004] The current cell transplantation therapy can promote angiogenesis and myocardial regeneration in the infarct area, thereby improving cardiac function after myocardial infarction, and its safety and effectiveness in the treatment of cardiovascular diseases have been proven, providing a huge contribution to the repair of damaged hearts. However, the low survival rate, low colonization rate, and difficulty in differentiating to cardiovascular cell lineages after transplantation have become the key factors restricting its efficacy

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