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Application of PRCC or up-regulation agent thereof in liver cancer treatment and application of PRCC in liver cancer diagnosis or prognosis

A technology for anti-liver cancer and treatment of liver cancer, applied in the field of disease diagnosis and treatment, can solve the problem of lack of PRCC effect and mechanism research, and achieve the effect of superior sensitivity and specificity

Active Publication Date: 2021-02-12
中国人民解放军海军军医大学第三附属医院
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  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no research on the role and mechanism of PRCC in liver cancer

Method used

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  • Application of PRCC or up-regulation agent thereof in liver cancer treatment and application of PRCC in liver cancer diagnosis or prognosis
  • Application of PRCC or up-regulation agent thereof in liver cancer treatment and application of PRCC in liver cancer diagnosis or prognosis
  • Application of PRCC or up-regulation agent thereof in liver cancer treatment and application of PRCC in liver cancer diagnosis or prognosis

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Experimental program
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Embodiment 1

[0036] 1. Materials and methods

[0037] 1. Liver cancer tissue microarray and immunohistochemical detection analysis

[0038] Sixty-six pairs of human liver cancer and paracancerous tissue samples were collected and liver cancer tissue chips were prepared. This study has been reviewed by the ethics committee and the patients have signed informed consent. The expression of PRCC in liver cancer and adjacent tissues was detected by immunohistochemistry (IHC). The AlgorithmS program of the ImageScope software (Aperio Company) was used to calculate the "positive Pixel" of the cancer tissue in the tissue chip to obtain the calculation data. The calculation method of histochemical score for each tissue is Log10[255 / Iavg], where Iavg represents the average intensity. The median of the score was selected to distinguish high or low expression of PRCC, combined with pathological and follow-up data, the correlation between the expression level of PRCC and clinical indicators and survi...

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PUM

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Abstract

The invention relates to application of PRCC or an up-regulation agent thereof in liver cancer treatment and application of PRCC in liver cancer diagnosis or prognosis. The research on liver cancer clinical tissue samples finds that PRCC is highly expressed in liver cancer and is related to poor prognosis of patients. The serum detection on liver cancer and normal people finds that PRCC can be used as a liver cancer diagnosis index and has excellent sensitivity, specificity and accuracy. Further overexpression or knock-down PRCC research finds that PRCC high expression can inhibit the formation of tumor stem cells, and can inhibit tumor formation and metastasis of liver cancer in vitro and in vivo. The invention provides a new thought for treatment, clinical diagnosis and prognosis of liver cancer.

Description

technical field [0001] The present invention relates to the field of diagnosis and treatment of diseases, specifically, the application of PRCC or its up-regulator in the treatment of liver cancer and the application of PRCC in the diagnosis or prognosis of liver cancer. Background technique [0002] Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and its morbidity and mortality have remained high for a long time. The high metastasis and recurrence rate, insensitivity to radiotherapy and chemotherapy, and high heterogeneity of liver cancer after surgery have become bottlenecks for further improving long-term efficacy. There is an urgent need to develop new therapeutic drugs and effective diagnostic and prognostic markers for liver cancer. Research in this area is of great significance for the clinical treatment of liver cancer and the prevention of tumor recurrence. [0003] At present, liver cancer drugs mainly include targeted drugs and immunoth...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12Q1/02G01N33/574A61K45/00A61P35/00
CPCC12Q1/6886G01N33/5011G01N33/57438A61K45/00A61P35/00C12Q2600/158
Inventor 刘春颖林雪晶苏长青
Owner 中国人民解放军海军军医大学第三附属医院
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