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Composition with function of lowering blood fat, and preparation method and application of composition

A composition and a blood lipid-lowering technology, which are applied in the directions of medical preparations, applications, and drug combinations containing active ingredients, can solve problems such as blood pressure rebound and increase blood pressure, and achieve the reduction of serum TC and TG content, and the inhibition of weight gain. , the effect of promoting lipid transport and excretion

Inactive Publication Date: 2021-01-05
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine does not solve the pathological factors that cause blood pressure to rise. Once the drug is stopped, the blood pressure will rebound quickly and the patient must take the drug for life

Method used

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  • Composition with function of lowering blood fat, and preparation method and application of composition
  • Composition with function of lowering blood fat, and preparation method and application of composition
  • Composition with function of lowering blood fat, and preparation method and application of composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh the following raw materials in parts by weight: 6 parts of cistanche, 5 parts of salvia miltiorrhiza, 7 parts of hawthorn, and 8 parts of seabuckthorn; mix the above raw materials, add water 8 times the total weight of the raw materials as an extraction solvent, and extract twice at 95 ° C , each time for 1.5h, filter, and combine the filtrates; the filtrate is concentrated under reduced pressure at 70°C and a relative vacuum of -0.07MPa to obtain a concentrated solution with a density of 1.1g / mL. The concentrated solution is spray-dried, and the hot air during spray-drying is controlled. The inlet temperature is 175° C. to obtain the material; the material is crushed and passed through an 80-mesh sieve to obtain a traditional Chinese medicine composition.

Embodiment 2

[0044] Weigh the following raw materials in parts by weight: 4 parts of cistanche, 3 parts of salvia miltiorrhiza, 4 parts of hawthorn, and 5 parts of seabuckthorn; mix the above raw materials, add water 12 times the total weight of the raw materials as an extraction solvent, and extract at 100 ° C for 3 hours, After filtration, the filtrate was obtained; the filtrate was concentrated under reduced pressure at 60°C and a relative vacuum of -0.08MPa to obtain a concentrated solution with a density of 1.2g / mL, and the concentrated solution was vacuum-dried at 80°C and a relative vacuum of -0.07MPa. After the 80 mesh sieve, the Chinese medicine composition was obtained.

Embodiment 3

[0046]Weigh the following raw materials in parts by weight: 4 parts of cistanche, 4 parts of salvia miltiorrhiza, 4 parts of hawthorn, and 4 parts of seabuckthorn; mix the above raw materials, add water 10 times the total weight of the raw materials as an extraction solvent, and extract 3 times at 95 ° C , filter for 1 hour each time, and combine the filtrate; the filtrate is concentrated under reduced pressure at 70°C and a relative vacuum of -0.08MPa to obtain a concentrated solution with a density of 1.08g / mL. The concentrated solution is spray-dried, and the hot air inlet during spray-drying is controlled. The temperature is 165° C. to obtain the material; the material is crushed and passed through an 80-mesh sieve to obtain a traditional Chinese medicine composition.

[0047] The present invention also optimizes the preparation process of the composition. The optimized preparation process obviously reduces the hygroscopicity of the composition, improves the fluidity of the...

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Abstract

The invention discloses a composition with a function of lowering blood fat, and a preparation method and application of the composition. The composition comprises the following ingredients in parts by weight: 2-8 parts of herba cistanches, 2-10 parts of radix salviae miltiorrhizae, 1-10 parts of fructus crataegi and 1-10 parts of fructus hippophae. The preparation method for the composition comprises the following steps of: (1) mixing medicine materials, adding water which occupies 6-20 times of total weight of the raw materials as an extraction solvent, carrying out extraction for 1-4 times,and carrying out filtering to obtain filtrate, wherein extraction is carried out for 0.5-3 hours each time; and (2) carrying out concentration on the filtrate to obtain concentrated solution, and carrying out drying. The composition disclosed by the invention can obviously lower the TC and TG content of the serum of a rat, a certain inhibition function is performed for the weight increment of therat, in addition, a HDL-C level in the serum of the rat can be obviously improved, and the composition has a function of lowering the blood fat.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine health care products, and in particular relates to a composition with hypolipidemic effect, a preparation method and application thereof. Background technique [0002] Hyperlipidemia is a common and frequently occurring metabolic disease, which refers to excessive blood lipid levels, which can directly cause some diseases that seriously endanger human health, such as atherosclerosis, coronary heart disease, pancreatitis, etc. Hyperlipidemia is common in middle-aged and elderly people, but with changes in diet structure and increased alcohol consumption, the prevalence rate among young people is also increasing year by year. Therefore, people pay more and more attention to the prevention and treatment of hyperlipidemia. [0003] There is no disease name for hyperlipidemia in traditional Chinese medicine. Hyperlipidemia is believed to be caused by deficiency in origin and excess...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61P3/06A23L33/105
CPCA61K36/64A61K36/537A61K36/734A61K36/185A61P3/06A23L33/105A23V2002/00A61K2236/331A61K2236/39A61K2236/53A61K2236/51A23V2200/326A23V2250/21A23V2300/14A61K2300/00
Inventor 肖伟邓辰辰王婧许明君相继芬丁艳柏伟荣
Owner JIANGSU KANION PHARMA CO LTD
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