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Bone hemostatic material

A technology of hemostatic materials and reagents, applied in the field of medicine, can solve problems such as poor adhesion and inconvenient clinical use

Inactive Publication Date: 2020-12-29
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hemostatic material has poor adhesion to the surface of bone injury and degrades quickly, which is not convenient for clinical use.

Method used

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Examples

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Comparison scheme
Effect test

Embodiment 1

[0088] This embodiment provides a bone hemostatic material, the bone hemostatic material comprises a first agent and a second agent, wherein, in parts by weight,

[0089] The first reagent comprises 5 parts of calcium phosphate, 20 parts of vitamin E acetate and 10 parts of calcium laurate;

[0090] The second reagent comprises 10 parts sodium carboxymethylcellulose, 10 parts poloxamer 237 and 20 parts water.

[0091] The preparation method of the bone hemostatic material of this embodiment is as follows:

[0092] 1) Mix 5 parts of calcium phosphate and 10 parts of calcium laurate evenly, heat 20 parts of vitamin E acetate at 30°C, add the evenly mixed mixture to the heated vitamin E acetate and mix evenly, cool at room temperature, and solidify the plastic After the type, the first reagent is obtained;

[0093] 2) Take 10 parts of sodium carboxymethylcellulose, 10 parts of poloxamer 237 and 20 parts of water and mix them uniformly to obtain the second reagent;

[0094] 3) ...

Embodiment 2

[0096] This embodiment provides a bone hemostatic material, the bone hemostatic material comprises a first agent and a second agent, wherein, in parts by weight,

[0097] The first reagent comprises 30 parts of calcium phosphate, 50 parts of vitamin E acetate and 30 parts of calcium laurate;

[0098] The second reagent comprises 30 parts sodium carboxymethylcellulose, 30 parts poloxamer 237 and 40 parts water.

[0099] The preparation method of the bone hemostatic material of this embodiment is as follows:

[0100] 1) Mix 30 parts of calcium phosphate and 30 parts of calcium laurate evenly, heat 50 parts of vitamin E acetate at 30°C, add the evenly mixed mixture to the heated vitamin E acetate and mix evenly, cool at room temperature, and solidify the plastic After the type, the first reagent is obtained;

[0101] 2) Take 30 parts of sodium carboxymethylcellulose, 30 parts of poloxamer 237 and 40 parts of water and mix them uniformly to obtain the second reagent;

[0102] 3...

Embodiment 3

[0104] This embodiment provides a bone hemostatic material, the bone hemostatic material comprises a first agent and a second agent, wherein, in parts by weight,

[0105]The first reagent comprises 10 parts of calcium phosphate, 30 parts of vitamin E acetate and 25 parts of calcium stearate;

[0106] The second reagent comprises 20 parts sodium carboxymethylcellulose, 15 parts poloxamer 335 and 25 parts water.

[0107] The preparation method of the bone hemostatic material of this embodiment is as follows:

[0108] 1) Mix 10 parts of calcium phosphate and 25 parts of calcium stearate evenly, heat 30 parts of vitamin E acetate at 40°C, add the evenly mixed mixture to the heated vitamin E acetate, mix evenly, cool at room temperature, and solidify After molding, the first reagent is obtained;

[0109] 2) Take 20 parts of sodium carboxymethylcellulose, 15 parts of poloxamer 335 and 25 parts of water and mix them uniformly to obtain the second reagent;

[0110] 3) The first rea...

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Abstract

The present invention provides a bone hemostatic material. The bone hemostatic material comprises calcium phosphate, vitamin E acetate, fatty acid salt, sodium carboxymethyl cellulose, poloxamer and water. the poloxamer is selected from one or more of poloxamer 105, poloxamer 124, poloxamer 184, poloxamer 237, poloxamer 335, poloxamer 338, poloxamer 401 and poloxamer 403; and the fatty acid salt is selected from one or more of magnesium laurate, calcium laurate, calcium palmitate, zinc palmitate, magnesium stearate, calcium stearate, zinc stearate, magnesium myristate and calcium myristate. The bone hemostatic material is good in adhesion performance and high in hemostatic performance, and can remarkably promote repair of bone wounds.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a bone hemostatic material. Background technique [0002] When bleeding is processed in a certain way, it is called hemostasis to quickly stop the blood from flowing outward. The process of hemostasis mainly includes three processes: vasoconstriction, platelet thrombus formation and blood coagulation. Hemostasis is an important step in medical treatment. Sufficient hemostasis is required for tissue and organ damage and surgery. Rapid hemostasis is also required when sudden trauma occurs in daily life. Trauma in harsh war environments and complex emergencies For emergency treatment, it is particularly important to achieve rapid and effective hemostasis; the hemostatic effect varies from person to person, some are fast, some are slow, and it is related to platelets. Under normal circumstances, bleeding caused by damage to small blood vessels will stop within a few minu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/08A61L24/04A61L24/00A61L27/12A61L27/20A61L27/18A61L27/54A61L27/58
CPCA61L24/0042A61L24/02A61L24/08A61L24/046A61L24/0015A61L27/12A61L27/20A61L27/18A61L27/54A61L27/58A61L2300/112A61L2300/232A61L2300/216A61L2300/412A61L2300/45A61L2430/02C08L71/02C08L1/286
Inventor 徐宝艳
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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