Layered bionic pore channel-porous composite scaffold

Abstract

The invention discloses a layered bionic pore channel-porous composite stent. The layered bionic pore channel-porous composite stent comprises an outer layer and an inner layer, wherein the outer layer is of a compact porous structure imitating compact bone, and the inner layer is of a loose porous structure imitating cancellous bone and is loaded with bone morphogenetic protein-2 (BMP-2); and thelayered bionic pore channel-porous composite stent is provided with a plurality of pore channels penetrating through the outer layer and the inner layer and used for inducing rapid ingrowth of bloodvessels. The layered bionic pore channel-porous composite stent has obvious advantages in the aspects of a layered structure, pore channel design, a BMP-2 loading mode and the like. Cortical bone is simulated through the relatively-compact structure of the outer layer, the mechanical property of the stent is met, ingrowth of tissue blood vessels is guaranteed through the loose porous structure ofthe inner layer, besides, rapid ingrowth of the blood vessels can be induced through the pore channel structure, osteogenic differentiation of cells growing along pore channels can be induced throughthe BMP-2 loaded in the porous area of the inner layer, and excessive osteogenesis caused by diffusion of the BMP-2 is avoided. Overall rapid vascularization bone regeneration of the stent is comprehensively realized.

Description

technical field [0001] The invention relates to the field of bionic supports, in particular to a layered bionic channel-porous composite support. Background technique [0002] Inflammation, tumor, trauma, congenital malformation, etc. often cause the defect and loss of the jaw bone. The incidence rate is high, which not only affects the appearance, but also leads to abnormal functions of chewing, swallowing and speech, which seriously affects the quality of life of patients. Large-scale defects even life threatening. For the treatment of jaw defects, there are currently two main clinical methods: 1. Autologous bone transplantation, which is the gold standard for clinical treatment, but has disadvantages such as limited source of autologous bone and trauma repair; 2. Bone substitute scaffold implantation. input, such as the use of hydroxyapatite scaffolds, etc. The jawbone is composed of relatively dense compact bone on the outer layer and relatively loose cancellous bone o...

AI Technical Summary

Problems solved by technology

However, the therapeutic effect of the brackets prepared by this method is unsatisfactory, especially the regenerative treatment of large jaw defects is still a major clinical problem

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