Application of polygonatum sibiricum polysaccharides in preparation of medicines for treating ulcerative colitis

A technology of ulcerative colitis and polysaccharide polysaccharide, applied in the field of biomedicine, can solve the problem that polysaccharide polysaccharide has not been fully utilized in the prevention and treatment of intestinal diseases, and achieve the effects of improving blood in the stool, increasing body weight, and improving the pathological structure of colon.

Active Publication Date: 2020-12-15
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, Polygonatum polysaccharides have not been fully utilized in the prevention and treatment of intestinal diseases

Method used

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  • Application of polygonatum sibiricum polysaccharides in preparation of medicines for treating ulcerative colitis
  • Application of polygonatum sibiricum polysaccharides in preparation of medicines for treating ulcerative colitis
  • Application of polygonatum sibiricum polysaccharides in preparation of medicines for treating ulcerative colitis

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Embodiment Construction

[0032] The above-mentioned content of the present invention will be further described in detail below through specific implementation in the form of examples. However, this should not be construed as limiting the scope of the above-mentioned subject matter of the present invention to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

[0033] The invention mainly provides the application of polygonatum polysaccharide in preparing medicine for treating ulcerative colitis, especially the application of Polygonatum polysaccharide in preparing medicine for inhibiting the release of inflammatory factors, regulating flora imbalance and repairing intestinal mucosal barrier damage. The medicine containing polygonatum polysaccharide can reduce the production of inflammatory factors IL-6 and TNF-α and increase the expression of anti-inflammatory factor IL-10 by regulating the activity of ne...

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Abstract

The invention belongs to the field of biological medicines, relates to application of polygonatum sibiricum polysaccharides in preparation of medicines for treating ulcerative colitis, and in particular relates to application of polygonatum sibiricum polysaccharides in preparation of medicines for inhibiting release of inflammatory factors, regulating flora imbalance and repairing intestinal mucosal barrier injury. By adjusting the activity of neutrophil Myeloperoxidase (MPO), generation of inflammatory factors IL-6 and TNF-alpha is reduced, expression of an anti-inflammatory factor IL-10 is increased, inflammatory expression is inhibited, colon inflammation is improved by improving intestinal barrier, and potential application of polygonatum sibiricum polysaccharides in treatment of ulcerative colitis is expected to be explored.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of Polygonatum polysaccharide in the preparation of medicines for treating ulcerative colitis, in particular to the application of Polygonatum polysaccharides in the preparation of medicines for inhibiting the release of inflammatory factors, regulating flora imbalance and repairing intestinal mucosal barrier damage . Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific intestinal inflammatory disease of unknown etiology. Cell disappearance and accumulation of soluble inflammatory mediators are pathological features [1] . At present, there is no effective treatment, and it is listed as one of the refractory diseases by WHO. In the past 20 years, the incidence and prevalence in China have continued to increase, and are closely related to the occurrence of colon cancer. The treatment of UC has become a difficult clinical problem. [2] . Althou...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/8969C08B37/00A61P1/04A61P1/00A61P29/00
CPCA61K31/715A61K36/8969C08B37/0003A61P1/04A61P1/00A61P29/00A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2236/55
Inventor 马善波张蕊石小鹏张伟屈慧缪珊
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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