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Gene marker for pancreatic cancer examination

A gene marker, pancreatic cancer technology, applied in the field of gene markers for pancreatic cancer detection, can solve the problems of low early diagnosis rate, lack of typical clinical symptoms, unsatisfactory curative effect, etc., achieve high sensitivity and specificity, easy recurrence and The effect of transfer, easy dynamic monitoring

Active Publication Date: 2020-11-24
凤凰智药生物科技(苏州)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the treatment of pancreatic cancer, early diagnosis is difficult, its onset is hidden, it lacks typical clinical symptoms, and its prognosis is extremely poor. Pancreatic cancer is highly aggressive and malignant, and the curative effects of surgery, chemotherapy and radiotherapy are not satisfactory. , the 1-year survival rate after surgery is less than 20%, and the 5-year survival rate is only 4%. The low early diagnosis rate and postoperative metastasis are the main reasons for the high mortality rate of pancreatic cancer

Method used

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  • Gene marker for pancreatic cancer examination
  • Gene marker for pancreatic cancer examination
  • Gene marker for pancreatic cancer examination

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Experimental program
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Effect test

Embodiment

[0083] The application of m1A regulating gene in the preparation of pancreatic cancer diagnosis, monitoring, curative effect evaluation or metastasis and recurrence monitoring reagents or kits; Application in the kit;

[0084] The reagent or kit includes primers that specifically recognize ALKBH1;

[0085] High expression of ALKBH1 factor is associated with better prognosis of patients.

[0086] The expression of ALKBH1 factor was negatively correlated with the clinical grade of the subjects;

[0087] The expression of ALKBH1 factor is related to the physiological process of histone methylation.

[0088] The m1A regulating gene factor can be applied to the diagnosis of pancreatic cancer, and the ALKBH1 factor of the m1A regulating gene of the present invention is used for the diagnosis of pancreatic cancer, which can be found earlier than clinical symptoms and signs, and provides a reference for doctors to intervene in advance.

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Abstract

The invention relates to the field of clinical diagnosis of pancreatic cancer, and particularly relates to a gene marker for pancreatic cancer examination, and application of an m1A regulatory gene inpreparation of a reagent or kit for diagnosis, monitoring, curative effect evaluation or metastasis and recurrence monitoring of pancreatic cancer. The invention further discloses application of an ALKBH1 factor in preparation of a reagent or kit for diagnosis, monitoring, curative effect evaluation or metastasis and recurrence monitoring of pancreatic cancer. The gene marker has the advantages of safety and non-invasion in pancreatic cancer detection, and the detection acceptability of asymptomatic people is high; the RNA source is wide, and a detection blind area in iconography does not exist; and the gene marker is suitable for diagnosis, monitoring, curative effect evaluation or metastasis and recurrence monitoring of pancreatic cancer. The gene marker can be combined with other clinical indexes, and more accurate judgment is provided for screening, diagnosis, treatment and prognosis of pancreatic cancer.

Description

technical field [0001] The invention relates to the field of clinical diagnosis of pancreatic cancer, in particular to a gene marker for pancreatic cancer inspection. Background technique [0002] Pancreatic cancer is a common tumor of the digestive tract and one of the malignant tumors with the worst prognosis. According to the latest epidemiological survey, pancreatic cancer ranks fourth in the mortality rate of malignant tumors in developed countries such as Europe and the United States, and about 2.5 million people die of pancreatic cancer every year in the world. In the past 20 years, the incidence of pancreatic cancer in my country has continued to increase, and pancreatic cancer currently ranks fifth in the mortality rate of malignant tumors. [0003] Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor of the digestive tract that is difficult to diagnose and treat. About 90% of pancreatic cancer is ductal adenocarcinoma (PDAC) originating from the ductal epi...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/112
Inventor 郭文治郑清元张起尧何玉婷
Owner 凤凰智药生物科技(苏州)有限公司
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