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Preparation method and application of multifunctional modified chitosan self-healing hydrogel

A hydrogel, self-healing technology, used in pharmaceutical formulations, medical science, prostheses, etc., can solve problems such as damage and stent deformation

Pending Publication Date: 2020-11-03
BIOPHARM RES & DEV CENT JINAN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional hydrogels have encountered some application challenges, such as the change of mechanical force after injection can lead to deformation or even destruction of the scaffold, endowing the hydrogel with self-healing ability can maintain its structural and functional integrity

Method used

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  • Preparation method and application of multifunctional modified chitosan self-healing hydrogel
  • Preparation method and application of multifunctional modified chitosan self-healing hydrogel
  • Preparation method and application of multifunctional modified chitosan self-healing hydrogel

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Embodiment Construction

[0022] Through in-depth research, the inventors have found that different growth factors have spatiotemporal specificity in the process of osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs), that is, bFGF promotes their proliferation and stemness maintenance, and TGFβ3 promotes their osteogenic differentiation. A self-healing hydrogel that sequentially releases bFGF and TGFβ3 was designed, injected in situ into alveolar bone defects, and repaired damaged alveolar bone tissue by sequentially releasing different growth factors, which is a pioneer in the field of periodontal tissue engineering. Basic research provides a new solution and means of restoration.

[0023] The specific technical scheme is as follows:

[0024] A preparation method of multifunctional modified chitosan self-healing hydrogel, characterized in that: its steps include:

[0025] 1) using chitosan as raw material, adopting emulsification cross-linking method to prepare chitosan micr...

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Abstract

The invention discloses a preparation method and application of multifunctional modified chitosan self-healing hydrogel. In order to realize the functions of different growth factors at different timestages, the microspheres are introduced as an encapsulating agent of a post-release drug (TGF beta 3) to be isolated from bFGF directly loaded in the gel to form an inner chamber structure, thereby achieving the goal of sequentially releasing different growth factors. The hydrogel prepared by the invention has good physical and chemical properties and good injectable properties, can be used for in-situ injection of bone injury repair, repairs injured bone tissues by sequentially releasing different growth factors, and provides a new solution and a new repair means for basic research in the field of bone tissue engineering.

Description

technical field [0001] The invention belongs to the field of tissue engineering and regenerative medicine, and in particular relates to a preparation method and application of a multifunctional modified chitosan self-healing hydrogel, especially for repairing and treating bone defects. Background technique [0002] Bone defect refers to a disease in which the integrity of bone structure is destroyed due to trauma, infection, tumor, congenital disease, etc., and is a common clinical symptom. Usually, severe bone defects cannot heal and repair by themselves, and must be restored effectively with the help of bone repair materials. According to statistics, globally, more than 22 million patients need bone transplant surgery every year, and the operation cost exceeds 2.5 billion US dollars; while in China, the number of patients who need bone transplant surgery due to bone defects or fractures can reach 3 million every year above. [0003] Stem cells are the seeds for the treat...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/18A61L27/22A61L27/52A61L27/54A61L27/58C08J3/075C08L5/08C08L71/02
CPCA61L27/18A61L27/20A61L27/227A61L27/52A61L27/54A61L27/58A61L2300/414A61L2300/602A61L2400/06A61L2430/02C08J3/075C08J2305/08C08J2471/02C08L5/08C08L89/00C08L71/02
Inventor 项琪黄亚东于凤麟
Owner BIOPHARM RES & DEV CENT JINAN
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