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Photodynamically active organosilica nanoparticles and medical uses thereof

A technology of silica and nanoparticles, applied in the field of medical applications, can solve the problem of lack of transdermal penetration

Pending Publication Date: 2020-10-23
NANYANG TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, all of these formulations lack transdermal penetration because hydrophilic systems and large molecules (>500 Da) cannot diffuse through the dense lipid-rich matrix of the stratum corneum

Method used

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  • Photodynamically active organosilica nanoparticles and medical uses thereof
  • Photodynamically active organosilica nanoparticles and medical uses thereof
  • Photodynamically active organosilica nanoparticles and medical uses thereof

Examples

Experimental program
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Effect test

example 1

[0206] Example 1: Microneedle-assisted local delivery of a photodynamically active mesoporous formulation for deep melanoma combination therapy

[0207] The prevalence of malignant melanoma is high, especially among Caucasians, with more than one million cases detected each year. It accounts for 4% of skin cancer incidence but 79% of skin cancer mortality. It is resistant to radiotherapy and chemotherapy, the latter showing severe side effects due to non-specific targeting. Surgical resection was also ineffective in 20% of all cases. More recently, targeted therapies have been employed to improve overall survival in melanoma. More than 60% of melanomas are associated with BRAF mutations, 90% of which are BRAF V600E Subtype. BRAF V600E It is due to overactivity of the mitogen-activated protein kinase (MAPK) pathway, leading to hyperstimulated cellular transformation and proliferation.

[0208] This paper describes novel and inventive techniques that address the above li...

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Abstract

The present application provides an organosilica nanoparticle comprising: (a) a photosensitizer for photodynamic therapy covalently incorporated therein; and (b) optionally, at least one agent encapsulated therein, as well as a pharmaceutical composition comprising said organosilica nanoparticle. Also provided herein are said organosilica nanoparticle or pharmaceutical composition for use as a medicament or in the treatment of a disease, disorder, or condition. More specifically, provided is a method for treating a disease, disorder, or condition in a subject using said aid organosilica nanoparticle or pharmaceutical composition.

Description

[0001] Cross References to Related Applications [0002] This application refers to and claims priority to Singapore Patent Application No. 10201710241V filed 08 December 2017, the contents of which are incorporated herein by reference for all purposes, including pursuant to PCT Rule 4.18, the incorporation not incorporated herein any element or part of the description, claims or drawings referred to in PCT Rule 20.5(a). technical field [0003] The present invention generally relates to photodynamically active organosilica nanoparticles comprising a photosensitizer and encapsulating at least one pharmaceutical agent, pharmaceutical compositions comprising said organosilica nanoparticles, and the use of said organosilica nanoparticles or the medical application of the pharmaceutical composition. Background technique [0004] Photodynamic therapy (PDT) has been widely used to treat malignant tumors. PDT involves the utilization of photosensitizers that generate singlet oxy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/69A61K47/54A61K45/06A61P35/00A61P35/04A61P17/00A61P17/12A61P43/00A61P17/02
CPCA61K41/0071A61K47/6929A61K47/6955A61K9/0009A61K9/0021A61K47/24A61K9/5123A61K9/0014A61K31/506A61K31/519B82Y5/00
Inventor 谭惠君徐克明林玮琪陈洪中S·文卡特拉曼徐臣杰赵彦利
Owner NANYANG TECH UNIV
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