Application of dry dendrobium aqueous extract in preparation of medicine for treating obesity

A technology of water extract and water extract, which is applied in the application field of dry dendrobium water extract in the preparation of obesity treatment medicines, and can solve problems such as obesity diseases of dendrobium or dendrobium extracts that have not yet been discovered

Inactive Publication Date: 2020-10-23
安徽同济生生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to our literature research, it has not been found that Dendrobium or Dendrobium extracts can be used in the treatment of obesity

Method used

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  • Application of dry dendrobium aqueous extract in preparation of medicine for treating obesity
  • Application of dry dendrobium aqueous extract in preparation of medicine for treating obesity
  • Application of dry dendrobium aqueous extract in preparation of medicine for treating obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prepare the dried dendrobium water extract, the specific steps are as follows:

[0027] Preparation of dry Dendrobium water extract: Weigh 20g of Dendrobium Huoshanense dry powder, extract with 400ml of distilled water in a 55°C water bath, filter and collect the filtrate, repeat the extraction 3 times, each time for 1 hour, and combine the extracts 3 times. The combined extracts were concentrated under reduced pressure at 55°C to 1 / 6-1 / 8 of the volume of the original liquid, and then freeze-dried to constant weight to obtain a dry Dendrobium water extract with a mass volume concentration of 100 mg / ml.

[0028] The dried dendrobium water extract prepared in the above-mentioned Example 1 with a mass concentration of 100 mg / ml was sterilized by filtration with a 0.22 μm filter membrane before the test, and then diluted to prepare a mass concentration of 10 μg / mL and 100 μg / mL. , 1000 μg / ml of a series of dry dendrobium water extract medicinal liquid, carry out refrigerate...

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PUM

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Abstract

The invention belongs to the technical field of pharmacy, and relates to an application of dry dendrobium aqueous extract in preparation of a medicine for treating obesity. Specifically, the dry dendrobium aqueous extract has an obvious inhibition effect on synthesis of triglyceride in a high-fat state. Experimental results show that the prepared dry dendrobium aqueous extract not only can obviously inhibit gene expression of fatty acid binding protein to generate a beneficial effect on fatty acid metabolism and inhibit occurrence of the obesity, but also can obviously inhibit gene expressionof diacylglycerol acyltransferase in HUH7 cells to inhibit synthesis of the triglyceride, increase the glucose uptake rate and the energy consumption and further resist the obesity caused by high-fatdiet, so that the prepared dry dendrobium aqueous extract can be applied to the preparation of the medicine for treating the obesity.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to the application of dry dendrobium water extract in preparing medicine for treating obesity. Background technique [0002] Obesity and its related metabolic diseases are gradually becoming one of the important threats to human health worldwide. In addition, with the change of living environment, the visceral fat type obesity of modern people will increase, and the incidence of metabolic syndrome (metabolic syndrome) accompanied by diabetes, hypertension, lipid metabolism disorder, insulin resistance, etc. will increase sharply, and these diseases will increase each other. It is a common disease related to multiple metabolic changes in the body such as aging, stress, and decreased immune function. As a representative obesity treatment agent in the past, Xenical, which uses Orlistat as the main ingredient, has side effects such as steatorrhea, flatulence, and abdominal distension,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P3/04
CPCA61K36/8984A61P3/04
Inventor 余茂耘梁英权韩际宏段亚君杨潇潇
Owner 安徽同济生生物科技有限公司
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