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Technology for enhancing brain magnetic therapy effect by magnetic nanomaterial

A magnetic nanometer and nanomaterial technology, applied in the field of biomedical nanomaterials, can solve the problems of lack of non-invasive technology for magnetic stimulation therapy, patient pain, and easy infection

Inactive Publication Date: 2020-10-20
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to current reports, in the literature on the use of magnetic nanomaterials to enhance magnetic stimulation, the usual method is to implant magnetic nanomaterials into the living body, which is highly invasive and can easily cause infection and inflammation.
Relying on external magnetic fields to increase magnetic stimulation will also cause pain and other effects on patients
At present, there is a lack of non-invasive technology for magnetic stimulation therapy, and it is of great significance for patients to develop non-invasive methods for magnetic stimulation therapy

Method used

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  • Technology for enhancing brain magnetic therapy effect by magnetic nanomaterial
  • Technology for enhancing brain magnetic therapy effect by magnetic nanomaterial
  • Technology for enhancing brain magnetic therapy effect by magnetic nanomaterial

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Embodiment Construction

[0032] In order to further illustrate the present invention, the technical method provided by the present invention will be further described in detail below in conjunction with examples and accompanying drawings. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0033] Example 1

[0034] Preparation of superparamagnetic iron oxide nanoparticles co-modified with polyethylene glycol and carboxylated chitosan

[0035] The specific operation is:

[0036] Superparamagnetic iron oxide nanoparticles were prepared by adding carboxylated chitosan with iron acetylacetonate as p...

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Abstract

The invention discloses a technology for enhancing the brain magnetic therapy effect by a magnetic nanomaterial, and belongs to the technical field of biomedical nanomaterials. According to the method, the magnetic nanomaterial overcomes barriers in a biological system and is delivered to the brain with need, and a magnetic field is applied to the part needing drug delivery to enhance successful delivery of the magnetic nanomaterial. On the basis of created design concept of combination of the external magnetic field and magnetic nanomaterial delivery, the brain magnetic stimulation effect issuccessfully enhanced, the magnetic nanomaterial used in the method is high in biocompatibility, simple to operate and high in safety, potential safety hazard caused by a current clinical invasive stimulation technology is avoided, and on the basis of non-invasive treatment and the advantage of biocompatibility of the material, potential clinical transformation of the magnetic nanomaterial enhanced magnetic stimulation technology can be promoted.

Description

technical field [0001] The invention belongs to the technical field of biomedical nano-materials, and in particular relates to a technology for enhancing magnetic stimulation by combining an external magnetic field and magnetic nano-materials. Background technique [0002] Magnetic stimulation treatment technology is to place the treatment equipment on the treatment site and form a magnetic field through the current to stimulate the activation of cells. It is a safe physical therapy. At present, the most common clinical method is Transcranial Magnetic Stimulation (TMS). The conductive area, beneath the brain tissue, induces electrical currents (called "eddy currents"). Although its underlying physiological mechanisms are not fully understood. Since its first report by Barker et al. in 1985, TMS has had widespread and varied success, including clinical success, in modulating brain activity. It has been reported that the use of TMS has successfully treated and recovered a g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/69A61K47/60A61K47/61A61P9/10A61P25/16A61P25/28A61P25/30B82Y25/00
CPCA61K41/0052A61K9/0009A61K47/60A61K47/61A61K47/6923B82Y25/00A61P9/10A61P25/16A61P25/28A61P25/30
Inventor 徐格林阮刚李榕榕王军洪叶
Owner NANJING UNIV
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