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Medicine for treating atherosclerosis and protecting blood vessels, preparation method and application

A technology for atherosclerosis and blood vessel protection, which is applied in the field of preparation of drugs for treating atherosclerosis and protecting blood vessels, and can solve problems such as inability to prevent and treat vascular restenosis

Pending Publication Date: 2020-10-13
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, if gastrointestinal administration is used, it may not be able to achieve a good effect in preventing and treating vascular restenosis due to the need for absorption compared with blood administration.
In addition, at present, there is no report on the use of zedoary compounds as oral anti-atherosclerotic agents.

Method used

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  • Medicine for treating atherosclerosis and protecting blood vessels, preparation method and application
  • Medicine for treating atherosclerosis and protecting blood vessels, preparation method and application
  • Medicine for treating atherosclerosis and protecting blood vessels, preparation method and application

Examples

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Embodiment Construction

[0027] The principle and spirit of the present invention will be described below with reference to several exemplary embodiments shown in the accompanying drawings. It should be understood that these implementations are described only to enable those skilled in the art to better understand and implement the present invention, but not to limit the scope of the present invention in any way.

[0028] 1. Preparation of zedoary guaiacane-type sesquiterpene drug-P3

[0029] 1.1 Extraction of Curcuma Extract

[0030] To prepare the extraction, weigh 2kg of zedoary block powder and extract in two batches. 1kg each time, add 10L, rotate in a 95°C water bath for 2 hours, and extract 3 times. Combine the extracted sample liquids, centrifuge the tubes, about 43.5L, and take 50mL reserved samples for analysis.

[0031] For ultrafiltration separation, add 43.5L centrifugal extract into the 4# feed liquid tank of the membrane separation instrument for ultrafiltration separation (hollow fi...

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Abstract

The invention discloses a medicine for preventing and treating atherosclerosis and protecting blood vessels. A guaiane type sesquiterpene medicine Zedoarondiol extracted from the traditional Chinese medicine curcuma zedoaria (Curcuma zedoaria / Christm.Rosc) or synthesized artificially is used as the effective component; and the medicine has a definite chemical molecular formula. A modern technologyis adopted n the invention; the medicine is steady in quality and high in content, and completely made of natural plants; the environment is protected; after being used continuously, the medicine does not have any toxic and side effect to a human body; and the medicine is the guaiane type sesquiterpene natural product easily absorbed by the human body, suitable for treating human dyslipidemia, arteriosclerosis and vascular endothelial disorder due to arteriosclerosis, and has the effects of adjusting lipid metabolism, stabilizing plaque, and preventing and treating coronary heart diseases.

Description

technical field [0001] The invention relates to the field of anti-atherosclerosis drugs, in particular to a drug for treating atherosclerosis and protecting blood vessels, a preparation method and application. Background technique [0002] Related literature reports that the incidence of ischemic heart disease and stroke in urban and rural populations has increased significantly, which indicates the incidence of ischemic cardiovascular disease (including coronary heart disease and ischemic stroke) based on atherosclerosis rate increases year by year. Cardiovascular disease has become the first cause of death in urban and rural populations in my country. Cardiovascular disease in China is characterized by a high incidence of stroke and a low incidence of coronary heart disease. However, the incidence and mortality of coronary heart disease have gradually increased in the past 20 years. A cohort study showed that elevated serum total cholesterol (TC) or low-density lipoprotein...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P9/10
CPCA61P9/10A61K31/122A61K36/9066A61P9/14Y02A50/30
Inventor 史大卓刘剑刚柴华崔源源梁鑫淼丰加涛刘艳芳
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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