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Application of specific lectin in identifying diabetic/non-diabetic nephropathy based on saliva glycoprotein sugar chains

A technology of diabetic nephropathy and lectin, which is applied in proteomics, disease diagnosis, genomics, etc., and can solve the problems of high technical requirements and high cost

Pending Publication Date: 2020-10-02
GENERAL HOSPITAL OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The gold standard for distinguishing DN from NDRD is renal biopsy, but it cannot be routinely carried out due to limitations such as invasiveness, high cost, and high technical requirements. Therefore, a simple, stable and reliable identification method is urgently needed in clinical work

Method used

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  • Application of specific lectin in identifying diabetic/non-diabetic nephropathy based on saliva glycoprotein sugar chains
  • Application of specific lectin in identifying diabetic/non-diabetic nephropathy based on saliva glycoprotein sugar chains
  • Application of specific lectin in identifying diabetic/non-diabetic nephropathy based on saliva glycoprotein sugar chains

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Experimental program
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Embodiment Construction

[0041] The relevant experiments and conclusions of the application are introduced below to reveal the scientificity and feasibility of the technical solution of the application. It should be understood that the research and development process and human and material resources spent by the applicant for this purpose are not limited to this.

[0042] 1. Screening of different sugar chain structures of salivary proteins in patients with diabetic nephropathy and non-diabetic nephropathy

[0043] Research methods:

[0044] 1.1. Collection and pretreatment of saliva samples

[0045] The saliva samples of patients with diabetic nephropathy (DN) and non-diabetic nephropathy (NDRD) used in this experiment were strictly approved by the PLA General Hospital (Human Research Ethics Committees (HRECs)). All volunteers who donated saliva samples, together with the clinicians who assisted in sampling guidance, were informed, agreed and highly cooperated with the research work, and completed t...

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Abstract

The invention provides application of specific lectin in identifying diabetic / non-diabetic nephropathy based on saliva glycoprotein sugar chains. The specific lectin is divided into an up-regulation group and a down-regulation group; the up-regulation group is at least one of NPA, HHL, PHA-E+L and PTL-II; the down-regulation group is at least one of MPL, SBA, LTL and AAL; if glycoprotein sugar chain structure expressions recognized by the up-regulation group and the down-regulation group are respectively and remarkably up-regulated and remarkably down-regulated, it is indicated that the nephropathy is particularly diabetic nephropathy (DN); otherwise, it is determined that the disease is non-diabetic nephropathy (NDRD); in addition, the following detection models are also constructed: if the detection value is less than or equal to 0.443, diabetic nephropathy is determined; otherwise, if the detection value is greater than 0.443, the patient is non-diabetic nephropathy.

Description

technical field [0001] The invention relates to a marker for distinguishing diabetic nephropathy and non-diabetic nephropathy based on sialoglycoprotein sugar chains and related products and applications. Background technique [0002] With the development of social economy and the improvement of people's living standards, the incidence of diabetes continues to increase, and the number of diabetic patients may exceed 693 million by 2045. Diabetic nephropathy (diabetic nephropathy, DN) occurs in 20% to 40% of patients with diabetes mellitus (DM). Studies have shown that kidney disease in diabetic patients is not necessarily diabetic nephropathy. Numerous studies have found that some patients with diabetes combined with kidney disease have different sensitivity to different treatment options compared with patients with diabetic nephropathy. In order to distinguish the two, this type of disease is called non-diabetic renal disease disease, NDRD), that is, patients with primary...

Claims

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Application Information

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IPC IPC(8): G01N33/68G16B5/00G16B20/00
CPCG01N33/6893G01N2333/4724G01N2440/38G01N2800/042G01N2800/347G16B5/00G16B20/00
Inventor 朱晗玉韩秋霞张冬丁潇楠
Owner GENERAL HOSPITAL OF PLA
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