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Application of CICs in pancreatic tumor tissue in preparation of product for predicting pancreatic cancer prognosis survival

A technology for pancreatic cancer and prognosis, applied in the field of application of CICs in pancreatic tumor tissue in the preparation of products for predicting the prognosis and survival of pancreatic cancer, can solve the problems of limited number and limited predictive value, and achieve accurate subtype analysis, significant originality Effect

Active Publication Date: 2020-10-02
BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSTY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] To sum up, currently, the prognostic indicators of pancreatic cancer that are routinely used clinically are not only limited in number, but also have limited predictive value.

Method used

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  • Application of CICs in pancreatic tumor tissue in preparation of product for predicting pancreatic cancer prognosis survival
  • Application of CICs in pancreatic tumor tissue in preparation of product for predicting pancreatic cancer prognosis survival

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0067] Example 1. Establishment of a method for predicting the prognosis of pancreatic cancer by CICs subtypes in tumor tissues

[0068] 1. Pretreatment of pancreatic tumor tissue sections to achieve deparaffinization and antigen retrieval

[0069] 1. Obtain paraffin pathological sections with pancreatic tumor tissue;

[0070] 2. Bake the paraffin sections at 65°C for 1.5 hours;

[0071] 3. After dewaxing xylene Ⅰ and Ⅱ for 5-10 minutes each, put them in 100%, 95%, 90%, 80%, 70% and other alcohol solutions for 3-5 minutes, then put them in distilled water 3 minute;

[0072] 4. Place the slices in antigen retrieval solution (Boschde, AR0024), boil in microwave for 15 minutes, and cool to room temperature naturally;

[0073] 5. Soak the slices in TBST solution (1×TBS, 0.1% (volume percentage)) Tween 20 for 2 minutes;

[0074] 6. Place the slices in blocking solution (1×TBS, 0.1% Tween 20 (volume percentage), 5% BSA (mass percentage)), and let stand at room temperature for 1 hour.

[0075] 2...

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Abstract

The invention discloses an application of CICs in pancreatic tumor tissue in preparation of a product for predicting pancreatic cancer prognosis survival. The invention provides an application of a substance for detecting whether oCIC exists in pancreatic cancer tissue of a pancreatic cancer patient or not or detecting the number of oCICs in preparation of a product for predicting the prognosis survival rate of the pancreatic cancer patient. The invention further provides an application of the substance for detecting whether TiT or TiT subtype number exists in pancreatic cancer tissue of the pancreatic cancer patient or not in preparation of a product for predicting the prognosis survival rate of the pancreatic cancer patient. The invention further provides application of the substance fordetecting the number of MiT subtypes in pancreatic cancer tissue of the pancreatic cancer patient to preparation of the product for predicting the prognosis survival rate of the pancreatic cancer patient. The invention further provides an application of the substance for detecting whether T / MiT exists in pancreatic cancer tissue of the pancreatic cancer patient or not in preparation of a productfor predicting the prognosis survival rate of the pancreatic cancer patient. Prognosis of pancreatic cancer patients is predicted through a CICs subtype analysis and counting method, and remarkable originality is achieved.

Description

Technical field [0001] The invention belongs to the field of biotechnology, and particularly relates to the application of CICs in pancreatic tumor tissues in preparing products for predicting the prognosis of pancreatic cancer. Background technique [0002] Pancreatic cancer is currently one of the worst-prognostic malignant tumors. The 5-year survival rate is less than 5%. The median survival time is less than 6 months without treatment. Ductal adenocarcinoma (PDCA) is the most common pathology. Types of. The reason for the poor prognosis of pancreatic cancer is that on the one hand, it is difficult to detect early, and 80-85% of patients have lost the opportunity of surgical resection when they are first diagnosed. On the other hand, drug resistance and lack of effective individualized treatment drugs are also factors that lead to poor prognosis One. Therefore, the accurate prediction of the prognosis of pancreatic cancer is of great significance to the judgment of the patie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57438Y02A90/10
Inventor 黄红艳孙强牛祖彪何美芳张波谷松至
Owner BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSTY
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