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Subarachnoid hemorrhage prediction model establishment method and system based on gene and cell signal pathways

A subarachnoid space and signaling pathway technology, applied in the field of bioinformatics, can solve the problems of lack of research auxiliary tools, unsatisfactory target research results, and few subarachnoid hemorrhage target models, etc. The effect of stickiness and reliability

Inactive Publication Date: 2020-08-25
SICHUAN UNIV
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Problems solved by technology

Most of the previous studies were mainly done with the help of clinical medicine and biological experiments, but the research results did not effectively reduce the mortality and disability rates of SAH
However, in the prior art, there are not many relevant studies on the method of establishing the target model of subarachnoid hemorrhage, and through a large number of clinical studies and summaries, the research effect on the target is not ideal, resulting in the lack of research in this field. of studies lack effective and accurate research aids

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  • Subarachnoid hemorrhage prediction model establishment method and system based on gene and cell signal pathways
  • Subarachnoid hemorrhage prediction model establishment method and system based on gene and cell signal pathways
  • Subarachnoid hemorrhage prediction model establishment method and system based on gene and cell signal pathways

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Embodiment Construction

[0061] Embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. It should be clear that the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0062] Those skilled in the art should know that the following specific embodiments or specific implementation methods are a series of optimized configurations listed by the present invention to further explain the specific content of the invention, and these configurations can be combined with each other or mutually Used in association, unless it is clearly stated in the present invention that some or a specific embodiment or implementation cannot be associated with or used in conjunction with other embodiments or im...

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Abstract

The invention provides a subarachnoid hemorrhage prediction model establishment method and system based on gene and cell signal pathways. The method comprises the steps: obtaining normal brain cell group 1 and SAH brain cell gene chip data, and preprocessing; carrying out differential expression analysis and signal path analysis on the data of the normal brain cell group 1 and the SAH brain cell gene chip; carrying out LCN2 intervention on a normal brain cell group 2 and SAH brain cells to obtain RNA-Seq data under different conditions, and preprocessing to form LCN2 data; carrying out differential expression analysis and signal path analysis on the LCN2 data; carrying out feature selection on the differentially expressed gene data obtained through the differential expression analysis to obtain feature gene data; and obtaining a training sample based on the feature gene data, training a plurality of classifiers based on the training sample, integrating the trained classifiers, and establishing a prediction model. According to the method, the subarachnoid hemorrhage model can be accurately established, and the treatment target can be obtained.

Description

technical field [0001] The invention belongs to the technical field of bioinformatics, mainly relates to biological data analysis and biological data mining, in particular to a method and system for establishing a subarachnoid hemorrhage model related to genes and signal pathways. Background technique [0002] Subarachnoid hemorrhage refers to the rupture of blood vessels at the base or surface of the brain, and blood flows into the subarachnoid space, with or without bleeding in other parts of the brain or spinal canal. [0003] In the related research on SAH, how to find effective targets that can predict or screen subarachnoid hemorrhage is also an important research direction at present. For example, NiW et al. found that IL-6 could be used as an early marker to predict cerebral vasospasm after SAH; Zhang et al. proved that IL-6 and CRP were involved in the occurrence and development of SAH; Chu et al. showed that HGF and VEGF were involved Pathological damage and repai...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/50G16B20/00
CPCG16H50/50G16B20/00
Inventor 章乐雷婉婧陈渝杰
Owner SICHUAN UNIV
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