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Magnetization transfer based metric for chemical exchange saturation transfer MRI

A liquid volume and frequency offset technology, applied in the field of medical analysis systems, can solve problems such as confusion of malignant lesions, and achieve the effect of improving and simplifying diagnostic reading.

Pending Publication Date: 2020-08-21
KONINKLJIJKE PHILIPS NV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although an important goal of APT MRI is to characterize malignancy, especially in oncology, other tissue types may appear hyperintensive in APT images and may be confused with malignancy

Method used

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  • Magnetization transfer based metric for chemical exchange saturation transfer MRI
  • Magnetization transfer based metric for chemical exchange saturation transfer MRI
  • Magnetization transfer based metric for chemical exchange saturation transfer MRI

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Embodiment Construction

[0068] In the following, like-numbered elements in the figures are either similar elements or perform equivalent functions. Elements already discussed previously will not have to be discussed in later figures if the function is equivalent.

[0069] Various structures, systems and devices are schematically depicted in the drawings for purposes of explanation only and so as not to obscure the present invention with details that are well known to those skilled in the art. Nevertheless, the accompanying drawings are included to describe and explain illustrative examples of the disclosed subject matter.

[0070] figure 1 is a schematic diagram of the medical analysis system 111 . Medical analysis system 111 includes processor 103 , memory 107 , each capable of communicating with one or more components of system 111 . For example, components of medical analysis system 111 are coupled to bi-directional system bus 109 .

[0071] It will be appreciated that the methods described he...

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Abstract

The present disclosure relates to a medical analysis system (111) for processing magnetic resonance imaging, MRI, data (170) from a target volume (208) in a subject (218). The system (111) comprises amemory (107) for storing machine executable instructions; and a processor (103) for controlling the system (111), wherein execution of the machine executable instructions causes the processor (103) to: determine from the MRI data (103) chemical exchange saturation transfer, CEST, voxel values corresponding to a transfer of saturation between a predefined pool of protons and water protons, the pool of protons having a predefined chemical shift; and weight the CEST values in order to distinguish CEST values of fluid-rich tissues (507) from CEST values of solid tissues (505) in the target volume(208), wherein the fluid-rich tissue comprises an amount of fluid higher than a predefined minimum amount of fluid.

Description

technical field [0001] The present invention relates to scanning imaging systems, and more particularly to medical analysis systems for processing magnetic resonance imaging (MRI) data to suppress data originating from fluid-rich tissue. Background technique [0002] Conventional magnetic resonance imaging (MRI) contrast is based on the spin relaxation rates of different body tissues under static magnetic fields and various radio frequency (RF) pulses. Known contrast depends on T1, T2, proton density (PD) and T2* weighting. To gain more information about the condition of the human body, novel image contrasts have been introduced using new imaging techniques such as amide proton transfer (APT) technology. The APT technique, also known as APT-weighted (APTw) MRI, is used, for example, for MR-based molecular imaging of endogenous cytosolic proteins or peptides. It is based on the chemical exchange saturation transfer (CEST) effect and reflects the protein concentration as wel...

Claims

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Application Information

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IPC IPC(8): G01R33/56A61B5/055
CPCG01R33/5605A61B5/055G01R33/4838G01R33/5608
Inventor J·库普
Owner KONINKLJIJKE PHILIPS NV
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