Flexible micro-column ring array for detecting clot contractility and preparation method and application thereof
A contractile force and micro-column technology, applied in the field of biomedicine, can solve the problems of difficult clinical transformation, complex device processing, and high inspection costs, and achieve the effects of objective and comprehensive test results, high sensitivity, and low inspection costs.
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Embodiment 1
[0072] Example 1 A flexible microcolumn ring array and its chip for detecting clot contraction force
[0073] Such as image 3 As shown, a flexible microcolumn ring array for detecting clot contraction force, wherein the microcolumn ring array is composed of several microcolumn rows arranged periodically, and each microcolumn row has several microcolumn rings , each micro-column ring is composed of four ring-shaped micro-columns; the micro-column ring has a circular hole with a certain diameter. In-house coagulation test. The diameter of the micro-column ring is 1 mm, and the distance between each micro-column ring is 1 mm; the column height of the micro-column is 1.2 mm, and the diameter of the upper surface of the column is 0.2 mm. The microcolumn ring array is a circular array; the microcolumn is cylindrical.
[0074] In addition, if image 3 As shown in (b) figure, this embodiment also provides a flexible microcolumn ring array chip for detecting clot contraction force...
Embodiment 2
[0075] Example 2 A flexible microcolumn ring array and its chip for detecting clot contraction force
[0076] Such as image 3 As shown, a flexible microcolumn ring array for detecting clot contraction force, wherein the microcolumn ring array is composed of several microcolumn rows arranged periodically, and each microcolumn row has several microcolumn rings , each micro-column ring is composed of four ring-shaped micro-columns; the micro-column ring has a circular hole with a certain diameter. In-house coagulation test. The diameter of the micro-column ring is 3 mm, and the distance between each micro-column ring is 5 mm; the column height of the micro-column is 1.6 mm, and the diameter of the upper surface of the column is 0.4 mm. The microcolumn ring array is a circular array, an elliptical array or a polygonal array; the microcolumn is in the form of a cylinder, an elliptical cylinder or a polygonal cylinder.
[0077] In addition, if image 3As shown in (b) figure, th...
Embodiment 3
[0079] Example 3 A flexible microcolumn ring array and its chip preparation method for detecting clot contractility
[0080] A method for preparing the flexible microcolumn ring array chip for detecting clot contraction force, comprising the following steps:
[0081] S1. Use Comsol simulation software to simulate the scene of micro-column bending under force, process and design the micro-column, determine the feasible size and actual spring coefficient of the micro-column, and the relevant parameters of the PDMS material;
[0082] S2. According to the design result of S1, a mold is obtained by cutting an acrylic plate with a laser, and finally the flexible microcolumn ring array chip for detecting clot contraction force is fabricated by reverse molding using PDMS.
[0083] The invention utilizes laser engraving and flexible material PDMS to process and obtain the microcolumn ring array or the microcolumn ring array chip. Specifically:
[0084] 1. Theoretical simulation
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