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Nitroglycerin tablet produced continuously

A technology of nitroglycerin and nitroglycerin dichloromethane, which is applied in the direction of nitrate ester preparation, pill delivery, organic chemistry, etc., to achieve the effect of solving a large amount of heat release

Inactive Publication Date: 2020-08-11
启东市新晨企业管理咨询有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This hazardous property is the most important obstacle to the production of nitroglycerin

Method used

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  • Nitroglycerin tablet produced continuously
  • Nitroglycerin tablet produced continuously
  • Nitroglycerin tablet produced continuously

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] A tablet of nitroglycerin is characterized in that: concentrated sulfuric acid and fuming nitric acid are mixed by microreactor chip (1); glycerin and dichloromethane are input into mixer (2), and microreactor chip (1 ) mixed acid solution and the solution of the mixer (2) are input in the microreactor chip (3), (4), (5), the reaction solution is retained in the microreactor, and the reaction solution is from the microreactor chip (5 ) into the Zaiput liquid-liquid separator (6), the acid liquid is input into the waste liquid processor, and after the organic phase is mixed with water input into the mixer (7), it is input into the Zaiput liquid-liquid separator (8), and the water phase is input into In the waste liquid processor, the organic phase and saturated salt solution are input to the Zaiput liquid-liquid separator (9), the water phase is input to the waste liquid processor, and the organic phase passes through the molecular sieve desiccant column (10), through the...

Embodiment 2

[0073] A tablet of nitroglycerin, characterized in that: concentrated sulfuric acid and fuming nitric acid are mixed at a speed ratio of 1:1 through a microreactor chip (1); glycerin and dichloromethane are input into the mixing chamber at a speed ratio of 0.2:2 device (2), the mixed acid solution of the microreactor chip (1) and the solution of the mixer (2) are input to the microreactor chip (3), (4), (5) at a speed ratio of 2:2.75, The retention time of the reaction solution in the microreactor is 10min to 30min, the reaction solution is input from the microreactor (5) to the Zaiput liquid-liquid separator (6), the acid solution is input to the waste liquid processor, and the organic phase is mixed with water to the input After the device (7) is mixed, it is input to the Zaiput liquid-liquid separator (8), the water phase is input to the waste liquid processor, the organic phase and saturated salt solution are input to the Zaiput liquid-liquid separator (9), and the water ph...

Embodiment 3

[0081] Green Tablets of Nitroglycerin (1)

[0082] The weight ratio of each component

[0083]

[0084]

[0085] Prepare as follows:

[0086] (1) Dry mix the green granules of nitroglycerin with microcrystalline cellulose passed through a 200-mesh sieve for 1 hour, stir well, and mix for 3 hours to make soft materials; make wet granules; dry at 40°C for 4 hours ; Pass the dry granules through an 80-mesh sieve; granulate to obtain drug-containing granules;

[0087] (2) Mix the drug-containing granules, crospovidone and magnesium stearate evenly, and press into tablets.

[0088] Nitroglycerin Tablets (2)

[0089] The weight ratio of each component

[0090]

[0091] Follow these steps:

[0092] (1) Dry mix the green granules of nitroglycerin with microcrystalline cellulose passed through a 200-mesh sieve for 1 hour, stir well, and mix for 3 hours to make soft materials; make wet granules; dry at 40°C for 4 hours ; Pass the dry granules through an 80-mesh sieve; gra...

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Abstract

The invention relates to a specific process for continuous production of nitroglycerin raw materials and tablets. Through hard innovation working, unexpected progress is achieved in the aspect of continuous production of green nitroglycerin preparations, green, safe and risk-free synthesis is achieved in key API preparation, combined API and nitroglycerin tablets are integrally produced, and the process is disclosed for the first time in China, is encouraged by global supervision departments, and is the most trend of drug production.

Description

technical field [0001] The invention belongs to the field of medicaments, in particular to a tablet of nitroglycerin produced continuously. Background technique [0002] Angina pectoris is a clinical syndrome characterized by paroxysmal chest pain or chest discomfort caused by coronary artery insufficiency and acute temporary ischemia and hypoxia of the myocardium. Nitroglycerin can directly relax vascular smooth muscle, especially small vascular smooth muscle, dilate peripheral blood vessels, reduce peripheral resistance, reduce cardiac output, reduce cardiac load, reduce myocardial oxygen consumption, and thus relieve angina. Nitroglycerin can promote the formation of collateral circulation. Take 1 tablet sublingually, it will take effect within 2-3 minutes, and the effect will last for about 30 minutes. [0003] Nitroglycerin, also known as glyceryl trinitrate, is formed by nitration of glycerin. The reaction equation is as follows: [0004] [0005] Glyceryl trini...

Claims

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Application Information

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IPC IPC(8): C07C201/02C07C203/06A61K31/21A61K9/20A61P9/10
CPCC07C201/02A61K31/21A61K9/2054A61K9/006A61P9/10C07C203/06
Inventor 张志祥
Owner 启东市新晨企业管理咨询有限公司
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