Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for analyzing and detecting new anti-AIDS drug

A technology for anti-AIDS and new drugs, applied to the measurement of color/spectral characteristics, etc., can solve the problems of high sensitivity, difficulty in popularization, and no drug reports, and achieve good recovery rate, drug stability, and clear purpose effects

Active Publication Date: 2020-08-07
西安昊洋药业科技有限公司
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The price of this liquid mass spectrometer is relatively high and it is difficult to popularize. It seems that there is no report on the method of separation and enrichment to study the drug. Separation and enrichment can not only improve the selectivity of the method, but also have high sensitivity.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for analyzing and detecting new anti-AIDS drug
  • Method for analyzing and detecting new anti-AIDS drug
  • Method for analyzing and detecting new anti-AIDS drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Main Experimental Instruments

[0023] Ultraviolet spectrophotometer (UV-1801 type), ultrasonic instrument, centrifuge L2-4K (Hunan Catcher Instrument Equipment Co., Ltd.), pipette (Thermo Fisher (Shanghai))

[0024] main reagent

[0025] ACC007 reference material (99.8%) and tablets (batch number 2019003) were kindly provided by Aidi Pharmaceutical Co., Ltd.

[0026] The reagents used in the experiment include buffer solution (self-configuration), ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate [C 8 mimPF 6 ], 1-butyl-3-methylimidazolium hexafluorophosphate [C 4 mimPF 6 ], 1-hexyl-3-methylimidazolium hexafluorophosphate [C 6 mimPF 6 ], ethanol, sodium chloride, thiourea, copper sulfate, zinc oxide, calcium carbonate, cadmium nitrate, potassium dihydrogen phosphate, sodium oxalate, lead nitrate, ferric chloride, lactose, all reagents are of analytical grade, purchased from Sinopharm Group. Water is distilled water.

[0027] Solution preparation

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for analyzing and detecting a new anti-AIDS drug ACC007. The method comprises the following steps of respectively adding 2.0 mL of an acetic acid-sodium acetate buffer solution with a pH value of 3.38-5.35, a proper amount of an ACC007 sample solution to be detected and 40-200 [mu] L of an ionic liquid in a centrifuge tube of 10.0 ml ; adding distilled water to scale marks, performing ultrasonic treatment for 3-25min, cooling the centrifuge tube to 0-4 DEG C, keeping the temperature at 0-4 DEG C for 10-20min, centrifuging with a centrifuge for 3-10min, layering, removing an upper-layer aqueous solution, and diluting a lower-layer ionic liquid phase with ethanol to 10mL to obtain a to-be-detected liquid; (2) detecting, taking the to-be-detected liquid obtained in the step (1), and detecting by using an ultraviolet-visible spectrophotometer to obtain absorbance; and (3) calculating the content, substituting the absorbance measured in the step (2) into aworking curve equation to obtain the content of ACC007.

Description

technical field [0001] The invention belongs to the field of drug analysis and detection, and relates to a method for analyzing and detecting ACC007, a new anti-AIDS drug, in particular to a method for separating, analyzing and detecting ACC007 using ultrasonic-assisted ionic liquid dispersion liquid-liquid microextraction. Background technique [0002] ACC007 is being developed for the treatment of HIV and it belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs). Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) are the first-line anti-HIV treatment drugs. About 50% of AIDS-infected people in the world are using this drug, and the proportion of this drug in my country is as high as 70%. The first generation of non-nucleoside anti-AIDS drugs is represented by efavirenz, while the second generation of non-nucleoside anti-AIDS drugs is represented by etravirine. According to researchers comparing the two generations of anti-AIDS drugs, they f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N21/33
CPCG01N21/33
Inventor 龚爱琴刘玉婷金党琴邓明晨
Owner 西安昊洋药业科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com