Method for evaluating regional population based on concentration of 4-pyridoxic acid in sewage

Abstract

The invention relates to a method for evaluating regional population based on a concentration of a 4-pyridoxic acid in sewage, and belongs to the field of population evaluation of an evaluated regionin environmental monitoring sewage epidemiology. After a sewage sample is subjected to solid-phase extraction separation and enrichment treatment, an ultra-high performance liquid chromatography-massspectrometer is used as a detection tool, the concentration of the 4-pyridoxic acid in the sewage is measured, and the real-time population of the evaluated region is estimated in combination with parameters such as a sewage inflow rate, a discharge rate of the human body 4-pyridoxic acid and the like. According to the method for evaluating the regional population based on the concentration of the4-pyridoxic acid in the sewage, a regional population change caused by population flow and other reasons can be eliminated so that more accurate population data is obtained, and environmental monitoring and research results based on sewage epidemiology are more accurate and reliable.

Description

technical field [0001] The invention belongs to the field of population estimation in the area to be evaluated, which is an important component in the epidemiological research of environmental monitoring sewage. Specifically, it relates to a method for estimating the population of an area based on the concentration of endogenous biomarker 4-pyridoxate in sewage. Background technique [0002] Sewage epidemiology is based on the content of endogenous substances, drugs, addictive products, drugs and their metabolites in sewage in a certain area, and obtains the concentration, total load and per capita load of target compounds through back calculation, so as to analyze the It is a method for monitoring and evaluating the conditions reflected by target compounds in a certain region or time period, such as the health status of the population, drug abuse, the prevalence of diseases related to drugs, and the consumption of hobby goods. At present, this method has been adopted by cou...

AI Technical Summary

Problems solved by technology

However, due to many reasons such as the concentration of human endogenous substances and environmental factors in sewage, most human endogenous substances cannot exist stably in sewage, which seriously affects the accuracy of the estimation results. Therefore, it is urgent to determine a suitable human endogenous substance. Sexual substances as biomarkers and improving their detection methods to improve the accuracy of population estimation

[0004] At present, when conducting sewage epidemiological research at home and abroad, the human metabolite cotinine of tobacco is often used as a biomarker to estimate the regional population. However, in the cotinine method, the calculation process of cotinine per capita production involves per capita Parameters such as the number of cigarettes smoked per day, the content of nicotine in tobacco, the intake of nicotine by the human body, the rate of metabolism of nicotine after inhalation into the human body, and other parameters are mostly determined by estimation, which makes the population estimation results prone to deviation

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