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Composition for promoting regeneration of injured articular cartilage tissues

A technology for tissue regeneration and articular cartilage, applied in drug combinations, bone diseases, plant raw materials, etc.

Active Publication Date: 2020-08-04
完美(广东)日用品有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It can be seen from the above that the existing research is still focused on the compounding of non-denatured type II collagen and cartilage collagen peptide to enhance its effect, and whether the traditional Chinese medicine raw materials in the above patent have a synergistic absorption effect on collagen rarely involved

Method used

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  • Composition for promoting regeneration of injured articular cartilage tissues
  • Composition for promoting regeneration of injured articular cartilage tissues
  • Composition for promoting regeneration of injured articular cartilage tissues

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] Mix non-denatured type II collagen, hydrolyzed type II collagen, turmeric, and snow lotus culture according to the mass ratio in Table 1.

[0024] Table 1 raw material composition distribution ratio

[0025] Undenatured Type II Collagen (g) Hydrolyzed Type II Collagen (g) Turmeric (g) Saussurea culture (g) Example 1 18 160 3 3 Example 2 60 486 9 9 Example 3 182 1460 28 29 Comparative example 1 / / 28 / Comparative example 2 / / / 29 Comparative example 3 182 1460 / / Comparative example 4 182 1460 28 / Comparative example 5 182 1460 / 29 Comparative example 6 / / 3 / Comparative example 7 / / / 3 Comparative example 8 18 160 / / Comparative example 9 18 160 3 / Comparative example 10 18 160 / 3

[0026] " / " means not added.

experiment example

[0028] Experimental purpose: To study the cartilage damage regeneration promoting effect of the composition of the present invention.

[0029] Experimental unit: Hangzhou Huante Biotechnology Co., Ltd.

[0030] Instruments and materials:

[0031] Dissecting microscope (SZX7, OLYMPUS, Japan); camera attached to the microscope (VertA1); precision electronic balance (CP214, OHAUS, AmericaCP214, OHAUS); fluorescence microscope (AZ100, Nikon, Japan); methylcellulose (Sigma, USA ); Dimethylsulfoxide (Sigma, France); 6-well plate (Nest Biotech).

[0032] Experimental samples: Examples 1-3 of the present invention, and Comparative Examples 1-10.

[0033] Positive control substance: chondroitin sulfate A sodium salt, white powder, batch number 6815, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0034] The experimental concentrations of the examples, comparative examples and control groups are shown in Table 2; the concentration of the positive control drug chond...

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Abstract

The invention discloses a composition for promoting regeneration of injured articular cartilage tissues. The composition is prepared from the following raw materials in parts by weight: 18-182 parts of non-denatured II type collagen, 160-1500 parts of hydrolyzed II type collagen, 3-28 parts of a saussurea involucrata culture and 3-30 parts of turmeric. On the premise of a certain antagonistic effect of the combination of turmeric or the saussurea involucrata culture and the non-denatured II-type collagen and the hydrolyzed II-type collagen, which are independently utilized, on articular cartilage tissue regeneration, the four components are creatively mixed for use, so that an obvious synergistic promoting effect is achieved on promoting regeneration of injured articular cartilage tissues,and the utilization rate of collagen is increased.

Description

technical field [0001] The invention discloses a composition for promoting regeneration of damaged articular cartilage tissue, which belongs to the field of health functional food. Background technique [0002] Osteoarthritis is a common bone and joint disease. It is a degenerative disease. It is caused by many factors such as aging, obesity, strain, trauma, congenital abnormalities of joints, joint deformities and other factors. Bone reactive hyperplasia. Clinical manifestations include slowly developing joint pain, tenderness, stiffness, joint swelling, limited mobility, and joint deformity. The current common treatment method is to consume collagen. For example, patent CN 201811175742.2 discloses a composition for preventing and treating osteoarthritis, which contains: non-denatured type II collagen and cartilage collagen peptide, and the experimental results show that the non-denatured type II collagen and cartilage collagen peptide The combination has a synergistic e...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61P19/04A61K36/9066
CPCA61K38/39A61K36/285A61K36/9066A61P19/04A61K2300/00
Inventor 余宗盛杜玉兰杨明龙曾瑜喻勤廖雪义吴晓春李翠华魏毅凡古润金
Owner 完美(广东)日用品有限公司
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