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Application of pyrazinamide and flumazenil combination to preparation of anti-convulsion drugs

A technology of flumazenil and pyrazinamide, applied in the field of medicinal chemistry, can solve problems such as adverse reactions of anticonvulsant drugs

Inactive Publication Date: 2020-07-07
ZHANG ZHOU HALTH VOCATIONAL COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention aims at the technical defects of the prior art, and provides the application of pyrazinamide and flumazenil in combination for the preparation of anticonvulsant drugs, so as to solve the technical problem of serious adverse reactions of anticonvulsant drugs in the prior art

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  • Application of pyrazinamide and flumazenil combination to preparation of anti-convulsion drugs
  • Application of pyrazinamide and flumazenil combination to preparation of anti-convulsion drugs
  • Application of pyrazinamide and flumazenil combination to preparation of anti-convulsion drugs

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Embodiment Construction

[0027] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments. Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0028] 1. Experimental grouping

[0029] Experimental group 1: an anticonvulsant drug consisting of pyrazinamide and flumazenil, wherein the mass ratio of pyrazinamide to flumazenil is 1:7; in this drug, the effective dose of pyrazinamide is 2mg / kg·d; in this drug, the effective dose of flumazenil is 14mg / kg·d.

[0030] Experimental group 2: an anticonvulsan...

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Abstract

The invention provides application of pyrazinamide and flumazenil combination to preparation of anti-convulsion drugs. The application of pyrazinamide and flumazenil combination to preparation of anti-convulsion drugs is characterized in that based on a research in an experimental means, findings prove that after the pyrazinamide and the flumazenil are used together in a specific proportion, severe symptoms in a convulsion incidence process can be effectively alleviated. Based on that, a pharmacological action principle is explored, experimental findings prove that although drugs are used unilaterally, the pyrazinamide and flumazenil combination does not have an effect of affecting neurotransmitter; and under the condition of combined application of the pyrazinamide and the flumazenil, theactivity of AMPA (Aminomethyl Phosphonic Acid) receptor and the activity of NMDA (N-methyl-D-aspartic acid) receptor can be obviously inhibited, and the combination has exact effects on reduction ofexcitatory postsynaptic currents and alleviation of delayed lesion of nerve cells. Based on the above-mentioned beneficial findings, according to the pyrazinamide and flumazenil combination disclosedby the invention, new application of the pyrazinamide and flumazenil combination to preparation of the anti-convulsion drugs is determined, and thus, a selection range of the anti-convulsion drugs iswidened, the medicine application of both of the pyrazinamide and the flumazenil is widened, and the pyrazinamide and flumazenil combination has wide application prospects.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, and further relates to the new medical application of substances, in particular to the application of pyrazinamide and flumazenil in combination for the preparation of anticonvulsant drugs. Background technique [0002] Convulsion (convulsion) is commonly known as cramps, convulsions, convulsions, also known as convulsions. It is manifested as paroxysmal limb and facial muscle twitches, often accompanied by upturned eyeballs, staring or strabismus on both sides, and confusion. Sometimes it is accompanied by foaming at the mouth or the corners of the mouth, apnea, and blue complexion. The attack time is usually within 3 to 5 minutes, and sometimes the attack occurs repeatedly, or even in a continuous state. [0003] Convulsions are acute and severe illnesses characterized by rhythmic movements of limbs and coma, and can occur in any season. Generally, short-term convulsions have almo...

Claims

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Application Information

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IPC IPC(8): A61K31/4965A61K31/5517A61K31/4468A61K31/05A61P25/08
CPCA61K31/05A61K31/4468A61K31/4965A61K31/5517A61P25/08A61K2300/00
Inventor 颜晓萍戴云翔房英娟林荣金李瑞凤郑美娟
Owner ZHANG ZHOU HALTH VOCATIONAL COLLEGE
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