Application of rifamycin antibiotics in preparation of drugs against yellow fever virus infections

A technology of rifamycin and yellow fever virus, applied in the field of medicine, can solve the problem of no effective specific antiviral drug treatment

Active Publication Date: 2020-06-23
THE NAVAL MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is an attenuated vaccine to prevent yellow fever virus infection, but there are no effective specific antiviral drugs for the treatment of infected people

Method used

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  • Application of rifamycin antibiotics in preparation of drugs against yellow fever virus infections
  • Application of rifamycin antibiotics in preparation of drugs against yellow fever virus infections
  • Application of rifamycin antibiotics in preparation of drugs against yellow fever virus infections

Examples

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Embodiment Construction

[0024] In order to illustrate the present invention more clearly, the present invention will be further described below in conjunction with preferred embodiments. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.

[0025] All the rifamycin antibiotics used in the examples of the present invention can be purchased from the market.

[0026] 1. Viruses, drugs, reagents and other materials

[0027] 1. Virus: Yellow fever virus, which was isolated from the plasma of a migrant worker in Fujian province imported from Angola, Africa, by the Department of Biomedical Protection, Naval Medical University of the Chinese People's Liberation Army in 2016, and was amplified and cultured by baby hamster kidney BHK cells.

[0028] 2. Compounds: 978 kinds of US FDA chemical drug molecular library, purchased from Selleck Company of the United States...

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Abstract

The invention relates to the technical field of medicine, and relates to an application of rifamycin antibiotics in the preparation of drugs against yellow fever virus infections. The rifamycin antibiotics refer to semi-synthetic or synthetic antibiotics containing rifamycin derivatives, and include a variety of broad-spectrum antibiotics of the rifamycin family, the curative effect for treating bacterial infections is sure, side effects are low, and the safety is good. The application of the rifamycin antibiotics in the drugs against yellow fever virus infections is reported for the first time in the world.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection drugs. Background technique [0002] Rifamycin antibiotics refer to semi-synthetic or synthetic antibiotics containing rifamycin derivatives, including a variety of antibiotics in the rifamycin family. The inhibitory effect on Gram-positive bacteria such as coccus is very strong, and it can also effectively inhibit some Gram-negative bacteria. [0003] Natural rifamycin antibiotics were originally isolated from the culture solution of Streptomyces mediterranei by an Italian pharmaceutical factory. Rifamycin B has strong activity and stable properties, but its clinical efficacy is not satisfactory. After artificially changing the chemical structure of the naturally produced rifamycin B, a series of antibiotics with stronger drug efficacy were obtained, called semi-synthet...

Claims

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Application Information

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IPC IPC(8): A61K31/395A61P31/14
CPCA61K31/395A61P31/14Y02A50/30
Inventor 赵平钱汐晶彭浩然唐海琳罗正汉徐铮昊吴兵安戚中田
Owner THE NAVAL MEDICAL UNIV OF PLA
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