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Application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection drugs

A technology of rifamycin and yellow fever virus, applied in the field of medicine, can solve the problem of no effective specific antiviral drug treatment

Active Publication Date: 2022-07-12
THE NAVAL MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is an attenuated vaccine to prevent yellow fever virus infection, but there are no effective specific antiviral drugs for the treatment of infected people

Method used

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  • Application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection drugs
  • Application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection drugs
  • Application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection drugs

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Embodiment Construction

[0024] In order to illustrate the present invention more clearly, the present invention will be further described below with reference to the preferred embodiments. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.

[0025] The rifamycin antibiotics used in the examples of the present invention can be purchased in a commercially available manner.

[0026] 1. Viruses, drugs, reagents and other materials

[0027] 1. Virus: Yellow fever virus, which was isolated from the plasma of a migrant worker from Fujian Province imported from Angola, Africa, by the Department of Biomedical Protection of the Naval Medical University of the Chinese People's Liberation Army in 2016. It was expanded and cultured in BHK cells of baby hamster kidney.

[0028] 2. Compounds: 978 kinds of US FDA chemical drug molecule library, purchased from US Selleck ...

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Abstract

The invention relates to the technical field of medicine, and relates to the application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection medicines. Rifamycin antibiotics refer to semi-synthetic or synthetic antibiotics containing rifamycin derivatives, including a variety of broad-spectrum antibiotics of the rifamycin family, which are effective in treating bacterial infections, with low side effects and good safety. . This patent reports the application of rifamycin antibiotics in anti-yellow fever virus infection drugs, which is the first report in the world.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection medicines. Background technique [0002] Rifamycin antibiotics refer to semi-synthetic or synthetic antibiotics containing rifamycin derivatives, including a variety of antibiotics of the rifamycin family, with broad-spectrum antibacterial effects against Mycobacterium tuberculosis, leprosy, streptococcus, pneumonia Gram-positive bacteria such as cocci have a strong inhibitory effect, and can also effectively inhibit some gram-negative bacteria. [0003] Natural rifamycin antibiotics were originally isolated from the culture solution of Streptomyces mediterranean by an Italian pharmaceutical company. Rifamycin B has strong activity and stable properties, but its clinical efficacy is not ideal. After artificially changing the chemical structure of naturally produced rifamy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/395A61P31/14
CPCA61K31/395A61P31/14Y02A50/30
Inventor 赵平钱汐晶彭浩然唐海琳罗正汉徐铮昊吴兵安戚中田
Owner THE NAVAL MEDICAL UNIV OF PLA
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