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Application of specific lectin combination in constructing test tool for identifying liver fibrosis (HF) based on saliva glycoprotein sugar chain

A liver fibrosis and lectin technology, which is applied in the application field of a specific lectin combination in the construction of a test tool for identifying liver fibrosis based on salivary glycoprotein sugar chains, and can solve problems such as abundance differences

Active Publication Date: 2020-06-05
深圳格道糖生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And there is also a significant difference in the abundance of the same protein between serum and saliva

Method used

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  • Application of specific lectin combination in constructing test tool for identifying liver fibrosis (HF) based on saliva glycoprotein sugar chain
  • Application of specific lectin combination in constructing test tool for identifying liver fibrosis (HF) based on saliva glycoprotein sugar chain
  • Application of specific lectin combination in constructing test tool for identifying liver fibrosis (HF) based on saliva glycoprotein sugar chain

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Embodiment Construction

[0034] The previous PCA analysis based on lectin chip data found that although there are certain differences in the glycoprotein glycoproteins of hepatitis B patients and patients with liver cirrhosis, there is still a part of overlap, and the hepatitis B patients in the overlap area have already developed lungs. Feature of liver fibrosis ( figure 1 ). Based on this, we designed and completed the following experiments. The following describes in detail the relevant verification experiments and analysis of this application, and the inventor's specific research and development process is not limited to this.

[0035] 1. Research method:

[0036] 1.1. Collection and pretreatment of saliva samples

[0037] The saliva samples of HB patients and HF patients used in this experiment have been strictly approved by Northwest University, Shaanxi Provincial People's Hospital and the Second Affiliated Hospital of Xi'an Jiaotong University (Human Research Ethics Committees (HRECs)). All volunte...

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Abstract

The invention discloses an application of a specific lectin combination in constructing a test tool for identifying liver fibrosis (HF) based on a saliva glycoprotein sugar chain. The specific lectincombination is selected from the group consisting of lectin RCA120, PHEE-E + L, EEL, AAL and DSA; compared with a hepatitis B sample, the liver fibrosis sample has the advantages that RCA120, PHE-E +L and EEL are remarkably reduced, and AAL and DSA are remarkably increased. Besides, an accurate test model is also constructed: if the detection value is greater than or equal to 0.1701, the main body to which the saliva sample belongs is indicated to be a liver fibrosis patient (HF), otherwise, if the detection value is smaller than 0.1701, the main body to which the saliva sample belongs is indicated to be a hepatitis B patient (HB).

Description

Technical field [0001] The invention relates to the application of a specific lectin combination in constructing a test tool for liver fibrosis. Background technique [0002] my country is a high-endemic area for chronic hepatitis, especially hepatitis B. About 120 million people have long-term carrier of Hepatitis B (HB) virus, and there are about 30 million patients with chronic hepatitis. Approximately 300,000 patients with chronic hepatitis have developed cirrhosis and liver cancer. Studies have found that 80%-90% of liver cancer patients experience the process of "chronic hepatitis-cirrhosis-liver cancer". Hepatic Fibrosis (HF) refers to the process of the development of chronic liver disease. Liver cells are repeatedly destroyed and regenerated. Extracellular matrix such as collagen, glycoproteins, and proteoglycans are diffusely deposited and abnormally distributed in the liver. The pathological repair response to chronic injury is a key step in the development of variou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G16H50/20
CPCG01N33/6893G16H50/20G01N2800/085
Inventor 李铮舒健
Owner 深圳格道糖生物技术有限公司
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