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A kind of detection method of whole Eucommia capsule

The technology of the whole Eucommia capsule and the detection method is applied in the detection field of the whole Eucommia capsule, which can solve the problems of insufficient quality assurance of the whole Eucommia capsule, and achieve the effects of good product quality, good reproducibility and accurate measurement results.

Active Publication Date: 2022-04-19
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No method has been found to detect the content of various lignans in Quanduzhong Capsules using the same chromatographic conditions, and the quality assurance of Quanducommia Capsules is still insufficient

Method used

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  • A kind of detection method of whole Eucommia capsule
  • A kind of detection method of whole Eucommia capsule
  • A kind of detection method of whole Eucommia capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A detection method for whole Eucommia capsules, the steps are as follows:

[0056] Measured according to Chinese Pharmacopoeia 2015 edition four general rules 0512 high performance liquid chromatography:

[0057] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel as filler; acetonitrile-water as mobile phase, gradient elution (0-30min, acetonitrile 12%-25%; 30-40min, acetonitrile 25% %~40%; 40~45min, acetonitrile 40%~100%); column temperature: 25°C; detection wavelength: 205nm; the number of theoretical plates is greater than 6000.

[0058] Preparation of reference substance solution: Accurately weigh the appropriate amount of reference substances of syringin, rosinin, rosinin monoglucoside and rosinin diglucoside, add methanol to dissolve and make each 1ml contain 0.02mg of syringin, 0.02mg of rosinin, and 0.02mg of rosinin A mixed solution of 0.06 mg of monoglucoside and 0.14 mg of pinoresin diglucoside.

[0059] The preparatio...

Embodiment 2

[0063] A detection method for whole Eucommia capsules, the steps are as follows:

[0064] Measured according to Chinese Pharmacopoeia 2015 edition four general rules 0512 high performance liquid chromatography:

[0065] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel as filler; acetonitrile-water as mobile phase, gradient elution (0-40min, acetonitrile 12%-30%; 40-50min, acetonitrile 30% %~40%; 50~52min, acetonitrile 40%~100%); Column temperature: 25°C; Detection wavelength: 205nm; The number of theoretical plates is greater than 6000.

[0066] Preparation of reference substance solution: Accurately weigh the appropriate amount of reference substances of syringin, rosinin, rosinin monoglucoside and rosinin diglucoside, add methanol to dissolve and make each 1ml contain 0.04mg of syringin, 0.06mg of rosinin, and 0.06mg of rosinin A mixed solution of 0.14 mg of monoglucoside and 0.26 mg of pinoresin diglucoside.

[0067] The preparatio...

Embodiment 3

[0071] A detection method for whole Eucommia capsules, the steps are as follows:

[0072] Measured according to Chinese Pharmacopoeia 2015 edition four general rules 0512 high performance liquid chromatography:

[0073] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel as filler; acetonitrile-water as mobile phase, gradient elution (0-40min, acetonitrile 12%-30%; 40-50min, acetonitrile 30% %~40%; 50~52min, acetonitrile 40%~100%); Column temperature: 25°C; Detection wavelength: 205nm; The number of theoretical plates is greater than 6000.

[0074] Preparation of reference substance solution: Accurately weigh the appropriate amount of reference substances of syringin, rosinin, rosinin monoglucoside and rosinin diglucoside, add methanol to dissolve and make each 1ml contain 0.03mg of syringin, 0.04mg of rosinin, and 0.04mg of rosinin A mixed solution of 0.10 mg of monoglucoside and 0.20 mg of pinoresin diglucoside.

[0075] The preparatio...

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Abstract

The invention relates to a method for detecting whole eucommia capsules, belonging to the technical field of medicine. The present invention adopts the same chromatographic condition to simultaneously measure the content of four kinds of lignan compounds such as pinoresinol diglucoside, pinoresin monoglucoside, syringin and pinoresin in the whole Eucommia capsule, and the operation is simple and fast, and the determination result is accurate and heavy. It has good presentability and can better reflect the product quality of Eucommia ulmoides capsules.

Description

Technical field: [0001] The invention relates to a method for detecting whole eucommia capsules, belonging to the technical field of medicine. Background technique: [0002] Eucommia ulmoides is a traditional precious Chinese medicine with a long history of medicinal use. "Shen Nong's Materia Medica" listed it as the top grade, saying that it "cures mainly low back and knee pain, nourishes the middle, nourishes essence, strengthens muscles and bones, eliminates itching and dampness under the yin, and relieves urination. Yu Li. Long-term use, light body and anti-aging.” Studies have shown that the chemical components in Eucommia include lignans, iridoids, phenylpropanoids, flavonoids, etc. Among them, lignans and Eucommia’s The effects of nourishing liver and kidney, strengthening bones and muscles, and lowering blood pressure are closely related. [0003] Quan Du Zhong Capsule is a single preparation of the traditional Chinese medicine Eucommia, which has the effects of nou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/74G01N30/06G01N30/14G01N30/34G01N30/86G01N30/88
CPCG01N30/02G01N30/74G01N30/06G01N30/14G01N30/34G01N30/8634G01N30/88G01N30/8679G01N2030/146G01N2030/884
Inventor 康兴东冯育林李小锋张金良周朝忠刘厚权刘九平
Owner JIANGXI POZIN PHARMA
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