Identification method and system for identifying <14>C nuclide in urea [<14>C] capsule

A technology of capsules and urea, which is applied in the measurement of radiation, the use of wave/particle radiation for material analysis, instruments, etc., to achieve objective conversion and avoid the effects of subjective factors

Active Publication Date: 2020-05-08
SHENZHEN ZHONGHE HEADWAY BIO SCI & TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a method for identifying urea[ 14 C] in capsule 14 C nuclide identification method and system

Method used

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  • Identification method and system for identifying &lt;14&gt;C nuclide in urea [&lt;14&gt;C] capsule
  • Identification method and system for identifying &lt;14&gt;C nuclide in urea [&lt;14&gt;C] capsule
  • Identification method and system for identifying &lt;14&gt;C nuclide in urea [&lt;14&gt;C] capsule

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Embodiment 1

[0037] figure 2 Shown is the method for distinguishing urea provided by an embodiment of the present invention [ 14 C] in capsule 14 The flowchart of the identification method of C nuclides, such as figure 2 Shown, the present invention provides for distinguishing urea [ 14 C] in capsule 14 The identification method of C nuclide comprises the following steps:

[0038] Step S1, preparing the test solution;

[0039] Specifically, in one embodiment of the present invention, take 1 urea [ 14 C] Capsules, dissolved with 3ml of water with slight heat, as need testing solution.

[0040] Step S2, respectively obtain the β energy spectrum of the test solution, 14 The β energy spectrum of the C standard source, the QPE of the test solution, 14 C the QPE of the standard source, and calculate the maximum energy of the test product;

[0041] Specifically, in an embodiment of the present invention, 20 μl of the test solution is measured and placed in a 20ml liquid scintillation v...

Embodiment 2

[0055] Based on the same inventive concept, the present invention also provides a method for identifying urea[ 14 C] in capsule 14 The identification system of C nuclide comprises a liquid scintillation measuring instrument and an identification module, and the liquid scintillation measuring instrument is used to obtain the β energy spectrum of the test solution, 14 The β energy spectrum of the C standard source, the QPE of the test solution and 14 The QPE of C standard source; Described discrimination module is used for according to the β energy spectrogram of need testing solution, 14 The β energy spectrum of the C standard source, the QPE of the test solution and 14 QPE for C standard sources generates identification results.

[0056] Specifically, in an embodiment of the present invention, the identification module includes:

[0057] Calculation unit, according to the QPE of the test solution and 14 The QPE of the C standard source calculates the maximum energy of the...

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Abstract

The invention discloses an identification method for identifying <14>C nuclide in a urea [<14>C] capsule. The identification method comprises the following steps: S1, preparing a test solution; S2, respectively acquiring a beta energy spectrogram of the test solution, a beta energy spectrogram of a <14>C standard source, QPE of the test solution and QPE of a <14>C standard source; and S3, generating an identification result according to the beta energy spectrum of the test solution, the beta energy spectrum of the <14>C standard source, the QPE of the test solution and the QPE of the <14>C standard source. According to the invention, the maximum energy of the test sample can be converted through the QPE of the test sample and the <14>C standard source, which is measured under the same condition; the method has the advantages that energy calibration does not need to be carried out on the liquid flash measuring instrument, conversion is more objective and accurate through the measuring result, and the influence of subjective factors for manually judging the energy end point is avoided.

Description

technical field [0001] The present invention relates to a kind of analysis method of radiopharmaceutical, more specifically, relate to a kind of method for distinguishing urea[ 14 C] in capsule 14 C nuclide identification method and system. Background technique [0002] Urea[ 14 C] is a radioactive substance whose identification includes 14 The identification of C nuclide and the identification of urea, wherein, for the identification of urea, paper chromatography can be used to judge by the Rf value of the colored spots; 14 The identification of C nuclides, due to 14 C belongs to low-energy β-nuclides, and the β-ray energy spectrum emitted by β-nuclides is a continuous spectrum, and the energy change can be distributed from 0 to a certain maximum value (ie, the endpoint energy); when the unknown sample contains two maximum β-energy When similar pure β nuclides are present, their identification will be very difficult. for example 14 C and 35 The maximum energy of S i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N23/00G01N33/15G01T1/36
CPCG01N23/00G01N33/15G01T1/362G01N2033/0093
Inventor 魏翠雯卿晶陈坚明沈桂富戴雄新王春玲杨永刚
Owner SHENZHEN ZHONGHE HEADWAY BIO SCI & TECH CO LTD
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