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Construction method for hypoxic fast-acclimation animal model

A technology of animal model and construction method, which is applied in animal husbandry and other fields, can solve the problems of model instability and repeatability, and achieve the effects of short cycle, simple modeling method and low cost

Inactive Publication Date: 2020-04-17
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

[0004] The purpose of the present invention is to overcome the above-mentioned deficiencies, provide a method for constructing a hypoxic rapid adaptation animal model, solve the problems of instability and poor repeatability in the previous models, and provide a solution for the next step in the rapid hypoxic adaptation program for humans The exploration provides experimental data and good reference

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  • Construction method for hypoxic fast-acclimation animal model

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Embodiment Construction

[0020] The present invention will be further described below in conjunction with accompanying drawing.

[0021] The present invention comprises the following steps:

[0022] Step 1: Randomly select a number of healthy SPF male SD rats with a body weight of 200-250 g, fast in advance, and only provide drinking water. The SD rats are kept in IVC cages with an ambient temperature of 22±5°C and a humidity of 50°C. ±5%, make the rats adapt and maintain for 24h;

[0023] Step 2, put the rats in a constant temperature and pressure change cabin, close the cabin door, simulate an ascent to an altitude of 4500m at a speed of 10m / s, keep the constant temperature in the cabin at 22±5°C, and the humidity at 50±5%. The air flow rate is 4L / min, only provide drinking water to the rats, and maintain the rats for 10 hours to get used to them;

[0024] Step 3, slowly descend to the current altitude at a speed of 20m / s, open the hatch and leave for 1 hour to make the rats get used to it;

[00...

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Abstract

The invention discloses a construction method for a hypoxic fast-acclimation animal model. The hypoxic fast-acclimation animal model constructed by the method has a simple molding method, the method only requires fasting in advance to make rats adapt to the environment, and acclimation is performed in a hypobaric chamber at the air pressure height of 4500 m; the method has a low cost and short cycle, the model can be formed at the fastest speed in 34 h, and the molding rate is high and can reach 100%; and the model provided by the invention has good repeatability and stability, and can gradually transition to human experiments.

Description

technical field [0001] The invention belongs to the field of biology, and in particular relates to a method for constructing an animal model for rapid adaptation to hypoxia. Background technique [0002] my country's plateau area is vast, accounting for about 1 / 4 of the country's land area. Among them, the average altitude of the Qinghai-Tibet Plateau is above 4000m, and the altitude of the Himalayas, which constitutes the border between China and India, has reached above 7000m. We know that every time the altitude increases by 5km, the atmospheric pressure decreases to about 1 / 2 of the original, and then the oxygen partial pressure also decreases; at an altitude of 7500m, the atmospheric pressure decreases from 760mmHg to 287mmHg, and the oxygen partial pressure decreases from 150mmHg to about 50mmHg. It is difficult to meet the needs of the body, resulting in acute high-altitude hypoxia. For mammals that have not been accustomed to hypoxia, they can only stay at this altit...

Claims

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Application Information

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IPC IPC(8): A01K67/027
CPCA01K67/027A01K2227/105A01K2267/03
Inventor 王小波余志斌赵汝舟程九华蒋帅
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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