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Plateau adaptability detection model training method and adaptability identification method and device

A technology for detecting models and adaptability, applied in the field of bioinformatics, can solve problems such as inability to explain plateau adaptive changes, and achieve the effect of predicting and preventing plateau hypoxic diseases

Pending Publication Date: 2020-04-14
GENERAL HOSPITAL OF PLA
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Problems solved by technology

[0004] However, neither the acclimatization theory nor the genetic polymorphism theory requiring long-term natural selection can explain these high-altitude adaptation changes in embryonic and infancy

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  • Plateau adaptability detection model training method and adaptability identification method and device
  • Plateau adaptability detection model training method and adaptability identification method and device

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[0036] In order to make the purpose, technical solution and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present application, and are not intended to limit the present application.

[0037] With the in-depth study of epigenetics on the mechanism of certain diseases, a large number of specific markers, such as chromosomal instability, microsatellite instability, and methylation modification, have been discovered and identified, realizing early detection of various diseases. Diagnosis offers the possibility. And some studies have found that a type of Mycobacterium tuberculosis lacking DNA (DeoxyriboNucleic Acid, deoxyribonucleic acid) methylase dies faster than other groups, that is, DNA methylase may play an important role in the process of adapting to ...

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Abstract

The invention relates to a plateau adaptability detection model training method and an adaptability recognition method and device, and the model training method comprises the steps: obtaining a firstsample biological sample set, and obtaining a first sample methylation expression profile of each sample biological sample in the first sample biological sample set through an epigenetics sequencing method; and training a deep neural network based on the first sample methylation expression profile to obtain a plateau adaptability detection model. The method comprises the following steps: a deep neural network is trained through epigenetic markers of a first sample biological sample set to obtain a plateau adaptability detection model; the methylation expression profile of the biological sampleto be identified is identified by using the plateau adaptability detection model so as to obtain the plateau adaptability identification result of the biological sample to be identified, such that the important significance is provided for predicting and preventing plateau hypoxic diseases.

Description

technical field [0001] The present application relates to the technical field of bioinformatics, in particular to a training method for a plateau adaptability detection model, an adaptability identification method and a device. Background technique [0002] In recent years, with the economic growth of the plateau area and the needs of national defense construction, a large number of people quickly entered the plateau area from the plain. Those with poor acclimatization in the early stage of entering the plateau mainly suffer from acute mountain sickness, including acute mountain sickness (AMS), high altitude pulmonary edema, and high altitude cerebral edema; Hypertension Syndrome (HAPC) and High Altitude Pulmonary Hypertension. Therefore, the most important problem to be solved when moving from the plains to the plateau is the impact of plateau hypoxia on human life activities. Therefore, the core tasks of plateau medicine are: the mechanism of plateau acclimatization and t...

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Application Information

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IPC IPC(8): G16B40/00G16B25/10G16B20/40
CPCG16B40/00G16B25/10G16B20/40Y02A90/10
Inventor 石金龙何昆仑贾志龙于康
Owner GENERAL HOSPITAL OF PLA
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